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CompletedNCT01849549CORACUpdated Feb 6, 2026

Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage

An interventional study of Neuropsychological testing and MRI in Cerebrovascular Disorders, Brain Lesions and Degenerative Diseases, sponsored by University Hospital, Rouen. Completed at 1 site in France. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-06.

Sponsored by University Hospital, Rouen · Not applicable, Interventional, and Diagnostic

Phase
Not applicable
Study type
Interventional
Enrollment
346
Allocation
Non-randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative disorders and selective cognitive disorders; (ii) healthy control subjects.

The objective of this project is to evaluate specific neuropsychological deficits and apply current brain imaging techniques (anatomical, diffusion, functional) to patients suffering from these cognitive deficits due to brain damage, in order to elucidate the brain mechanisms underlying these deficits.

02

Conditions studied

  • Cerebrovascular Disorders
  • Brain Lesions
  • Degenerative Diseases
  • Developmental Pathology

Keywords

  • neuropsychological Study
  • brain Imaging
03

In context

Cerebrovascular Disorders

374 studies on the registry are indexed under Cerebrovascular Disorders; 129 are open to participants now.

This study's enrollment of 346 is above the median of 110 across 214 interventional studies indexed under Cerebrovascular Disorders.

Browse Cerebrovascular Disorders studies →

Lead sponsor

University Hospital, Rouen is the lead sponsor of 410 studies on the registry; 104 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • age between 18 and 80 years
  • french language
  • effective contraception for women during the study
  • informed consent
  • no alcohol intake the day before the exam
  • for patients only, focal cerebral lesion (stroke, malformation, tumor, inflammatory, infectious, traumatic), neonatal pathology or degenerative disease with cognitive deficit

Exclusion criteria

Exclusion Criteria:

  • for healthy volunteers: previous neurological history (except non complicated migraine), previous psychiatric history (except depression with good evolution or anxiety with maximum one anxiolytic treatment), or severe cranial traumatism
  • for patients: vigilance disorders, severe depression or anxiety.
  • for both: psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month, severe visual or auditory impairment, patient without judicial or administrative liberty, measure of legal protection or no capable to express their consent, pregnancy or breastfeeding, contraindication for MRI, participation in another trial or former involvement in another trial within one month
05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
346 participants (actual)

Study arms

  • Experimental
    brain damaged subjects

    patients with circumscribed brain injury, selective disorders of cognitive development or degenerative disorders responsible for focal troubles

    Behavioral: Neuropsychological testing · Other: MRI

  • Sham comparator
    healthy volunteers

    healthy controls

    Behavioral: Neuropsychological testing · Other: MRI

Interventions

  • BehavioralNeuropsychological testing

    Experimental test about cognitive deficit of interest and standard neuropsychological tests.

  • OtherMRI

    Anatomical, diffusion, and/or functional MRI

06

What researchers measure

Primary outcomes

  1. Cognitive deficit

    The cognitive deficit of interest will depend on the localization of the brain lesion. The outcome measure could be a standardized neuropsychological test or an experimental test specifically elaborated for this protocol.

    Time frame: 3 to 6 months

07

Study locations

1 site
  • CHU - Hôpitaux de Rouen
    Rouen, 76031, France
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 6, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01849549
Lead sponsor
University Hospital, Rouen
Responsible party
Sponsor
First posted
May 8, 2013
Start date
May 2013
Primary completion
Mar 1, 2022
Completion
Mar 1, 2022
Last update
Feb 6, 2026

Study contacts

David Wallon, Doctor
principal investigator · Neurology Department

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.

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