CClinicalTrials.gg
Approved for marketingNCT018253953 4-DAPUpdated Oct 6, 2021

Use of 3,4-Diaminopyridine in the Treatment of Lambert-Eaton Syndrome

An expanded access record providing 3, 4-Diaminopyridine in Lambert Eaton Myasthenic Syndrome, sponsored by University of Colorado, Denver. Approved for marketing at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-10-06.

Sponsored by University of Colorado, Denver · Expanded access

Study type
Expanded access
Ages
18 Years and older
Sex
All
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Study summary

To learn more about the effect of 3, 4-Diaminopyridine (3,4-DAP) on patient diagnosed with Lambert-Eaton myasthenic syndrome (LEMS).

02

Conditions studied

  • Lambert Eaton Myasthenic Syndrome
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In context

Lambert-Eaton Myasthenic Syndrome

29 studies on the registry are indexed under Lambert-Eaton Myasthenic Syndrome; 6 are open to participants now.

Browse Lambert-Eaton Myasthenic Syndrome studies →

Lead sponsor

University of Colorado, Denver is the lead sponsor of 1,499 studies on the registry; 315 are open to participants now.

Of its 139 completed or terminated interventional studies of FDA-regulated products, 89 (64%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Age 18 years or older,
  • Diagnosed with LEMS,
  • If female, have a negative pregnancy test, and
  • If premenopausal, be willing to practice an effective form of birth control during the study,
  • Tested and found by ECG not to have a prolonged QT syndrome,
  • Agree to have a second ECG at the time of peak drug effect,
  • Has understood and signed the Informed Consent.

Exclusion criteria

Exclusion Criteria:

  • Is known to have a sensitivity to 3, 4-DAP,
  • Has a history of:

    1. past or current seizures,
    2. cardiac arrhythmia,
    3. hepatic, renal or hematologic disease, or
    4. severe asthma,
  • Is believed by the investigator to be unable to comply with the protocol.
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Access details

Study type
Expanded access

Available treatment

  • Drug3, 4-Diaminopyridine
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Where to request access

1 site
  • University of Colorado
    Aurora, Colorado 80045, United States
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 6, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT01825395
Lead sponsor
University of Colorado, Denver
Responsible party
Sponsor
First posted
Apr 5, 2013
Last update
Oct 6, 2021

Study contacts

Steven P Ringel, MD
principal investigator · University of Colorado, Denver
View the source record on ClinicalTrials.gov ↗

Requesting access

Expanded access is arranged between your doctor and the company. Ask your care team to contact the provider listed on this record.

No contact was published for this record. The registry link below has the sponsor’s details.

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