An observational study in Adrenal Suppression, sponsored by The Nazareth Hospital, Israel. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2013-02-26.
Sponsored by The Nazareth Hospital, Israel · Observational
To evaluate the effect of intra-articular corticosteroid injection (IACI) of depot preparation of betamethasone on the hypothalamic-pituitary-adrenal (HPA) axis, in patients with osteoarthritis of the knee
Consecutive patients attending the rheumatology or orthopedic clinic with osteoarthritic knee pain, not responding satisfactorily to medical or physical therapy were allocated to group-1 after consent and given IACI of 6 mg of betamethasone acetate/betamethasone sodium phosphate. Following completion of this part, consecutive age- and sex-matched patients were allocated to group-2 and given intra-articular injection of 60 mg of sodium hyaluronate. Just prior to the knee injection and 1, 2, 3, 4 and 8 weeks later, patients had 1 µg adrenocorticotropin hormone (ACTH) stimulation test. Secondary adrenal insufficiency (SAI) was defined as levels of less than 18 ng/ml or a rise of \< than 7 ng/ml of serum cortisol, 30 minutes following the ACTH stimulation test.
The Nazareth Hospital, Israel is the lead sponsor of 6 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with osteoarthritis of the knee and had not been onsteroids for at least 3 months
Exclusion Criteria:
Patients who had intra-articular injection of betamethasone
Patients who had intra-articular injection of hyaluronic acid
Adrenal Suppression
Adrenal gland suupresion and inability to adequately secrete cortisol in response to stress
Time frame: 2 months
favorable clinical response
Time frame: 2 months
Favorable clinical response
Improvement of knee pain by more than 30 points according to visual analogue scale
Time frame: 2 months following the steroid injection
Nadir serum cortisol level
Time frame: 2 months
No study locations are listed for this record.
This study is completed, as verified in Feb 2013. You cannot join it, but the record below documents what was studied.
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The Nazareth Hospital, Israel