An interventional study of Dietary intervention in Subjects With Mild Hypertriglyceridemia in Type 2 DM, sponsored by Yonsei University. Completed at 1 site in Korea, Republic of. Open to participants aged 25 Years to 72 Years. Per ClinicalTrials.gov, last updated 2013-02-06.
Sponsored by Yonsei University · Not applicable, Interventional, and Basic science
We examined whether a substitution of whole grains and legumes for refined rice in a high carbohydrate diet (about 65% of energy derived from carbohydrate) may modify the effect of this variant on changes in apolipoprotein A-V (apoA-V) and triglyceride concentrations.
We genotyped the APOA5 -1131T>C in individuals with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes, who were randomly assigned to either a group ingesting whole grain and legume meals daily or a control group for 12 weeks.
296 studies on the registry are indexed under Hypertriglyceridemia; 39 are open to participants now.
This study's enrollment of 200 is above the median of 66 across 259 interventional studies indexed under Hypertriglyceridemia.
Browse Hypertriglyceridemia studies →Yonsei University is the lead sponsor of 1,387 studies on the registry; 232 are open to participants now.
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Exclusion Criteria:
Dietary Supplement: Dietary intervention
Dietary Supplement: Dietary intervention
The intervention program consisted of replacing of refined rice intake with 1/3 of legumes, 1/3 of barleys, and 1/3 of whole grains three times per day as a high carbohydrate source and increased vegetable intake to at least 6 units (30-70 g/unit) per day for sufficient dietary fiber intake. The subjects were recommended to drink no more than one alcoholic beverage drink (15 g alcohol) per day and were assigned physical activity consisting of a regular 30-min walk after dinner each day. Participants were also instructed to record their physical activity diary for 24 h every 4 weeks.
Triglyceride
Time frame: change from baseline in TG at 12 weeks
Apolipoprotein A5
Time frame: Change from baseline in ApoA5 at 12 weeks
Apolipoprotein A5 gene
Time frame: ApoA5 -1131T>C polymorphism
This study is completed, as verified in Feb 2013. You cannot join it, but the record below documents what was studied.
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Yonsei University