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CompletedNCT01778452Updated Feb 15, 2013

Endometrial Genomic Profile in Endometrial Priming

An interventional study of endometrial biopsy in Genomic Human Endometrial Expression Profile, sponsored by Instituto Valenciano de Infertilidad, IVI VALENCIA. Completed at 1 site in Spain. Open to female participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-02-15.

Sponsored by Instituto Valenciano de Infertilidad, IVI VALENCIA · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
6
Allocation
Non-randomized
Ages
18 Years to 35 Years
Sex
Female
01

Study summary

The aim of this study is to analyse genomics profile expression in endometrium under different endometrial priming for recipients.

Read the detailed description

We analyze the genomic profile of egg donors in different endometrial priming protocols, compared with natural cycle, including the conventional single long acting GnRH agonist injection in the mid luteal phase of the previous cycle of the endometrial priming and the single daily antagonist injection (Cetrorelix 0.25 mg) administered in the early follicular phase followed by endometrial priming. Endometrial biopsy will be taken in luteinizing hormone

  • 7 or with P4 +5 in cases with endometrial priming with oestrogens therapy.
02

Conditions studied

  • Genomic Human Endometrial Expression Profile

Keywords

  • Endometrial priming, genomic expression. Natural cycle. Antagonist GnRH.
03

In context

Lead sponsor

Instituto Valenciano de Infertilidad, IVI VALENCIA is the lead sponsor of 70 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes

Inclusion criteria

  • 6 egg healthy volunteer egg donors.
  • Volunteers.
  • 18-35 years old
  • Healthy.
  • BMI \<28.

Exclusion criteria

Exclusion Criteria:

    • BMI > 28
  • Smokers-
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Non-randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
6 participants (actual)

Study arms

  • Active comparator
    Natural cycle

    Natural cycle endometrial biopsy, lh+7

    Procedure: endometrial biopsy

  • Experimental
    Antagonist cycle + endometrial priming.

    Antagonist cycle + endometrial priming for egg donation program. endometrial biopsy, p4+5

    Procedure: endometrial biopsy

  • Experimental
    Agonist cycle + endometrial priming.

    Agonist cycle + endometrial priming for egg donation program endometrial biopsy, p4+5

    Procedure: endometrial biopsy

Interventions

  • Procedureendometrial biopsy

    endometrial biopsy

06

What researchers measure

Primary outcomes

  1. genetic endometrial human profile expression

    implantation related genes profile expression

    Time frame: Oocyte donors will be followed up for four to six months

07

Study locations

1 site
  • Ivi Valencia
    Valencia, 46015, Spain
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 15, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01778452
Lead sponsor
Instituto Valenciano de Infertilidad, IVI VALENCIA
Collaborators
Igenomix
Responsible party
Sponsor
First posted
Jan 29, 2013
Start date
Nov 2009
Primary completion
Oct 2012
Completion
Jan 2013
Last update
Feb 15, 2013

Study contacts

Carmen Vidal, MDphD
principal investigator · IVI Valencia

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2013. You cannot join it, but the record below documents what was studied.

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