An observational study in Aortic Stenosis, sponsored by Royal Brompton & Harefield NHS Foundation Trust. Withdrawn at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2014-12-02.
Sponsored by Royal Brompton & Harefield NHS Foundation Trust · Observational
In patients with aortic stenosis the valve through which blood is pumped out of the main heart chamber is narrowed. This results in heart muscle working harder to open the valve so blood can circulate around the body. The muscle adapts to the increased pressure load to maintain efficiency. This can cause long-term muscle damage. To predict when this deterioration will require a valve replacement is difficult and untimely operation exposes patients to unnecessary risk.
We aim to compare all validated techniques looking at different aspects of heart muscle strain in these patients. These will be a blood sample measuring a specific hormone (BNP) and enzyme (Troponin), a nuclear scan to assess nerve activation, an MRI identifying scarring and an exercise echocardiogram that measures heart muscle response and pressure changes across the valve. Tests will be performed at recruitment and either after one year or after valve replacement, which ever comes first.
In comparing these different imaging techniques we aim to identify patients who will benefit from an early operation, those whose muscle is likely to recover back to normal and which patients it is safe to wait longer for the surgery, avoiding unnecessary risk.
The results of the study will benefit patients as it will help doctors more accurately assess the timing of valve surgery and improve their prediction of long term heart muscle recovery. It may also increase convenience in clinical management by reducing unnecessary tests and hospital trips. This would translate into cost savings for the NHS.
985 studies on the registry are indexed under Aortic Valve Stenosis; 283 are open to participants now.
Browse Aortic Valve Stenosis studies →Royal Brompton & Harefield NHS Foundation Trust is the lead sponsor of 137 studies on the registry; 18 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Tertiary care Outpatient population under regular follow by either cardiology or cardio thoracic team.
Inclusion Criteria:
(Group A)
(Group B)
Exclusion Criteria: (Group A and B)
Patients with symptomatic severe aortic stenosis (AS) as per ESC guidelines, requiring aortic valve replacement.
Radiation: Cardiac I123-MIBG Scintigraphy · Other: Cardiac MRI · Other: Stress and rest Echocardiogram · Other: High Sensitivity Troponin I · Other: Brain Natriuretic Peptide
Asymptomatic patients with moderate to severe aortic stenosis (AS) as per ESC guidelines ,with Left Ventricular ejection fraction \>50%, not yet requiring aortic valve replacement.
Radiation: Cardiac I123-MIBG Scintigraphy · Other: Cardiac MRI · Other: Stress and rest Echocardiogram · Other: High Sensitivity Troponin I · Other: Brain Natriuretic Peptide
Need for aortic valve replacement
Time frame: 1 year
Improvement in measured indices post aortic valve replacement
Time frame: 6 months
The change in rate of measured indices over time
Time frame: 6 months - 1 year
The relative change in measured indices between each other over time
Time frame: 6 months - 1 year
This study is withdrawn, as verified in Nov 2014. You cannot join it, but the record below documents what was studied.
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Royal Brompton & Harefield NHS Foundation Trust