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CompletedNCT01770938Updated Sep 23, 2014

Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training

An interventional study of Effective light-emitting diode therapy and Placebo light-emitting diode therapy in Healthy, sponsored by Universidade Federal de Sao Carlos. Completed at 1 site in Brazil. Open to male participants aged 18 Years to 28 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-09-23.

Sponsored by Universidade Federal de Sao Carlos · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
32
Allocation
Randomized
Ages
18 Years to 28 Years
Sex
Male
01

Study summary

Muscle performance is largely influenced by modulations in gene expressions of muscle tissue. In this context, light-emitting diode therapy (LEDT) has been used to improve muscle performance in experimental models and human researches. Thereby, the investigators examined modulations in gene expression of muscle tissue as well as biochemical, biomechanic and histologic adaptations influenced by exercise associated to LEDT.

Read the detailed description

This study assessed muscle performance in isokinetic dynamometry and led press device, gene expression by RT-PCR, lactate, creatine kinase and morphology of muscle tissue by immunohistochemical analysis

02

Conditions studied

  • Healthy

Keywords

  • Light-emitting diode therapy
  • Muscle performance
  • Gene expression
  • Functional performance
03

In context

Lead sponsor

Universidade Federal de Sao Carlos is the lead sponsor of 85 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 28 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

  • healthy males aged between 18 and 28 years with a body mass index (BMI) equal to or less than 26 kg/m2,
  • moderated pattern of physical activity

Exclusion criteria

Exclusion Criteria:

  • previous injury to the femoral quadriceps or hamstring muscles (within 6 months prior to study),
  • osseous or articular disorder in the lower limbs,
  • cardiovascular system disorders,
  • systemic disease, and
  • taking prescription medicines or using dietary supplements such as muscle mass builders.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double (Participant, Investigator)
Enrollment
32 participants (actual)

Study arms

  • Active comparator
    Effective light-emitting diode therapy and training

    Effects of effective light-emitting diode therapy therapy on muscle performance of young males submitted to physical strength training

    Device: Effective light-emitting diode therapy

  • Placebo comparator
    Placebo light-emitting diode therapy and training

    Effects of placebo light-emitting diode therapy on muscle performance of young males submitted to physical strength training

    Device: Placebo light-emitting diode therapy

Interventions

  • DeviceEffective light-emitting diode therapy

    Also known as: LED, LED therapy, Light-emitting diode therapy

  • DevicePlacebo light-emitting diode therapy

    Also known as: LED, LED therapy, Light-emitting diode therapy

06

What researchers measure

Primary outcomes

  1. Modulations on muscle gene expression by RT-PCR

    Time frame: 12 weeks

Secondary outcomes

  1. Muscle performance in leg press device

    Time frame: 12 weeks

  2. Muscle performance in leg extension device

    Time frame: 12 weeks

  3. Muscle performance in isokinetic dynamometer

    Time frame: 12 weeks

  4. Gene expression

    Gene expression of muscle tissue by RT-PCR

    Time frame: 12 weeks

Other outcomes

  1. Immunohistochemical analysis

    Immunohistochemical analysis to quantify morphology and cells of muscle tissue as satellite cells.

    Time frame: 12 weeks

07

Study locations

1 site
  • Federal University of São Carlos
    São Carlos, São Paulo 13565-905, Brazil
08

References and documents

Publications

  • Vieira WH, Ferraresi C, Perez SE, Baldissera V, Parizotto NA. Effects of low-level laser therapy (808 nm) on isokinetic muscle performance of young women submitted to endurance training: a randomized controlled clinical trial. Lasers Med Sci. 2012 Mar;27(2):497-504. doi: 10.1007/s10103-011-0984-0. Epub 2011 Aug 26. PubMed 21870127 ↗
  • Ferraresi C, de Brito Oliveira T, de Oliveira Zafalon L, de Menezes Reiff RB, Baldissera V, de Andrade Perez SE, Matheucci Junior E, Parizotto NA. Effects of low level laser therapy (808 nm) on physical strength training in humans. Lasers Med Sci. 2011 May;26(3):349-58. doi: 10.1007/s10103-010-0855-0. Epub 2010 Nov 18. PubMed 21086010 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 23, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01770938
Lead sponsor
Universidade Federal de Sao Carlos
Collaborators
Fundação de Amparo à Pesquisa do Estado de São Paulo, Centro de Pequisas de Ótica e Fotônica
Responsible party
Cleber Ferraresi (MSc, Universidade Federal de Sao Carlos) — Principal investigator
First posted
Jan 18, 2013
Start date
May 2012
Primary completion
Jul 2012
Completion
Sep 2014
Last update
Sep 23, 2014

Study contacts

Cleber Ferraresi, MSc
principal investigator · Universidade Federal de Sao Carlos
Nivaldo A Parizotto, PhD
study director · Universidade Federal de Sao Carlos
Vanderlei S Bagnato, PhD
study director · University of Sao Paulo

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2014. You cannot join it, but the record below documents what was studied.

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