A Phase 3 interventional study of HIT-exercise, low repetition range and HIT-exercise, high repetition range in Sarcopenia and Obesity, sponsored by University of Erlangen-Nürnberg Medical School. Completed at 1 site in Germany. Open to male participants aged 30 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-03-21.
Sponsored by University of Erlangen-Nürnberg Medical School · Phase 3, Interventional, and Treatment
A plethora of trials reported the positive effect of resistance exercise on functional and morphological parameters. Although a large amount of the studies used suboptimum devices and obsolete methods the results of these older studies were still considered as golden standard. The aim of the present study is thus to determine the proper effect of different resistance exercise protocols with and without adjuvant protein supplementation on functional and morphological muscle and body composition parameters in male untrained subjects 30-50 years old under special regard of modern medical imaging and segmentation technologies.
Our general study hypothesis is that HIT-resistance exercise significantly impact relevant muscular parameters of the upper leg.
1,208 studies on the registry are indexed under Sarcopenia; 402 are open to participants now.
This study's enrollment of 120 is above the median of 60 across 775 interventional studies indexed under Sarcopenia.
Browse Sarcopenia studies →University of Erlangen-Nürnberg Medical School is the lead sponsor of 267 studies on the registry; 51 are open to participants now.
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Exclusion Criteria:
High Intensity Resistance Exercise Training, low repetition range, \> 75% 1 Repetition Maximum (1RM)
Other: HIT-exercise, low repetition range
High Intensity Resistance Exercise Training, high repetition range, 60 - \<75% 1RM
Other: HIT-exercise, high repetition range
High Intensity Resistance Exercise Training with protein supplementation
Other: HIT-exercise with protein
No physical exercise intervention
Other: Control
High Intensity Resistance Exercise Training, low repetition range, \> 75% 1RM
High Intensity Resistance Exercise Training, high repetition range, 60 - \< 75 1RM
High Intensity Resistance Exercise Training, low repetition range, \> 75% 1RM and Protein Supplementation
control group, no intervention, maintenance of physical activity
fat free Cross Sectional Area (CSA) upper leg
fat free muscle cross sectional area of the upper leg at mid-femur via Quantitative Computed Tomography (QCT)
Time frame: change from baseline in fat free Cross Sectional Area at 5 months
CSA upper leg
muscle cross sectional area of the upper leg at mid-femur via QCT
Time frame: change from baseline in CSA upper leg at 5 months
intra-abdominal fat mass
intra-abdominal fat mass via Magnetic Resonance Imaging (MRI)
Time frame: change from baseline in intra-abdominal fat mass at 5 months
maximum strength leg press
Maximum dynamic strength of the leg extensors/-flexors
Time frame: change from baseline in maximum strength leg press at 5 months
metabolic syndrome score
Metabolic Syndrome Score according to Johnson et al.
Time frame: change from baseline in metabolic syndrome score at 5 months
myocardial mass/enddiastolic volume
Time frame: change from baseline in myocardial mass/enddiastolic volume at 5 months
This study is completed, as verified in Mar 2014. You cannot join it, but the record below documents what was studied.
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University of Erlangen-Nürnberg Medical School