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CompletedNCT01762098Updated Jul 27, 2015

Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization

An observational study in Infertility, Endometritis and Abortion, Spontaneous, sponsored by Clinique Ovo. Completed at 1 site in Canada. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2015-07-27.

Sponsored by Clinique Ovo · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
100
Ages
18 Years to 45 Years
Sex
Female
01

Study summary

Chronic endometritis is a persistent inflammation of the endometrium. Chronic endometritis is asymptomatic or little symptomatic. Sometimes, patient with chronic endometritis can have genital bleeding, pelvic chronic pain, pain during sexual relations, persistent vaginal white loosing. The hysteroscopy can detect the presence or absence of chronic endometritis.

Some studies showed that the endometritis could have an impact on the embryo implantation and could explain recurrent miscarriages or repeated embryo implantation failures.

The goal of this study is to evaluate the frequency of the chronic endometritis in patients with recurrent miscarriages or repeated embryo implantation failures

02

Conditions studied

  • Infertility
  • Endometritis
  • Abortion, Spontaneous

Keywords

  • In vitro fertilization
  • Hysteroscopy
  • Endometrial biopsy
03

In context

Infertility

2,541 studies on the registry are indexed under Infertility; 405 are open to participants now.

This study's enrollment of 100 is below the median of 200 across 722 observational studies indexed under Infertility.

Browse Infertility studies →

Lead sponsor

Clinique Ovo is the lead sponsor of 36 studies on the registry; 1 is open to participants now.

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Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
Female
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Population with recurrent miscarriage or repeated embryo implantation failures.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

Group repeated miscarriages

  • Women aged 18 to 43 years
  • ≥ 2 miscarriages before 14 weeks of gestation
  • Genetic (karyotype x2), thrombophilic and endocrine assessment should be completed

Group of implantation failure in In-vitro fertilization

  • Women aged 18 to 45 years
  • Absence of pregnancy after 3 good quality embryos transferred in women under 35 years and 4 embryos in the 35 years and over.

Exclusion criteria

Exclusion Criteria:

  • Positive pregnancy test
  • Unexplained bleeding
  • Incomplete miscarriage assessment
  • Uterine malformation
  • Antibiotic treatment during or within one month prior to the biopsy
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
100 participants (actual)
Patient registry
No

Groups and cohorts

  • Recurrent miscarriages
  • Repeated embryo implantation failures
06

What researchers measure

Primary outcomes

  1. Rate of chronic endometritis

    Time frame: 1 day

Secondary outcomes

  1. Pregnancy rate

    Time frame: 1 year

07

Study locations

1 site
  • Clinique Ovo
    Montreal, Quebec H4P 2S4, Canada
08

References and documents

Publications

  • Bouet PE, El Hachem H, Monceau E, Gariepy G, Kadoch IJ, Sylvestre C. Chronic endometritis in women with recurrent pregnancy loss and recurrent implantation failure: prevalence and role of office hysteroscopy and immunohistochemistry in diagnosis. Fertil Steril. 2016 Jan;105(1):106-10. doi: 10.1016/j.fertnstert.2015.09.025. Epub 2015 Oct 9. PubMed 26456229 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 27, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01762098
Lead sponsor
Clinique Ovo
Responsible party
Sponsor
First posted
Jan 7, 2013
Start date
Nov 2012
Primary completion
Mar 2014
Completion
May 2015
Last update
Jul 27, 2015

Study contacts

Pierre-Emmanuel Bouet, MD
principal investigator · Université de Montréal

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2015. You cannot join it, but the record below documents what was studied.

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