A Phase 2 interventional study of Effect of Stevioside and Rebaudioside on plaque pH in Dental Caries, sponsored by Università degli Studi di Sassari. Completed. Open to participants aged 20 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-01-15.
Sponsored by Università degli Studi di Sassari · Phase 2, Interventional, and Prevention
The aim of the present investigation was to evaluate the effect of stevioside and rebaudioside on several variables related to caries development. Two approaches were performed: an in vitro evaluation of the growth of a culture of mutans streptococci and in vivo randomized study on the effect of a single rinse containing stevioside and rebaudioside on plaque-pH.
1,109 studies on the registry are indexed under Dental Caries; 197 are open to participants now.
This study's enrollment of 20 is below the median of 60 across 916 interventional studies indexed under Dental Caries.
Browse Dental Caries studies →Università degli Studi di Sassari is the lead sponsor of 27 studies on the registry; 7 are open to participants now.
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good general health, normal salivary secretion rate, normal buffer capacity
Exclusion Criteria:
systemic diseases, salivary secretion reduction, reduced buffer capacity
After measuring baseline plaque pH, the subjects rinsed for 1 minute with the solution containing Stevioside extract. Plaque pH was then measured at 5, 10, 15, 30, 45 and 60 min after the mouth rinse.
Dietary Supplement: Effect of Stevioside and Rebaudioside on plaque pH
After measuring baseline plaque pH, the subjects rinsed for 1 minute with the solution containing Rebaudioside extract. Plaque pH was then measured at 5, 10, 15, 30, 45 and 60 min after the mouth rinse.
Dietary Supplement: Effect of Stevioside and Rebaudioside on plaque pH
After measuring baseline plaque pH, the subjects rinsed for 1 minute with the sucrose solution. Plaque pH was then measured at 5, 10, 15, 30, 45 and 60 min after the mouth rinse.
Dietary Supplement: Effect of Stevioside and Rebaudioside on plaque pH
After measuring baseline plaque pH, the subjects rinsed for 1 minute with the sucrose solution. Plaque pH was then measured at 5, 10, 15, 30, 45 and 60 min after the mouth rinse.
Plaque-pH modification
Plaque pH was measured at baseline and 5, 10, 15, 30, 45 and 60 minutes after each mouth rinse
Time frame: 5, 10, 15, 30, 45, 60 minutes
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This study is completed, as verified in Jan 2013. You cannot join it, but the record below documents what was studied.
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Università degli Studi di Sassari