An interventional study of Retro-articular drilling and Trans-articular drilling in Juvenile Osteochondritis Dissecans, sponsored by Boston Children's Hospital. Completed at 14 sites in 2 countries. Open to participants aged 8 Years to 18 Years. Per ClinicalTrials.gov, last updated 2020-12-03.
Sponsored by Boston Children's Hospital · Not applicable, Interventional, and Treatment
Among 13 studies in Osteochondritis Dissecans with a site in United States — 4 open to participants now, 4 under way, 1 of them phase 3. Osteochondritis Dissecans · United States.
Among the 13 studies in Osteochondritis Dissecans with a site in United States, this one is the only one that started in 2013, is one of 6 with no phase, and was the 5th registered.
30 studies on the registry are indexed under Osteochondritis Dissecans; 7 are open to participants now.
Browse Osteochondritis Dissecans studies →4 of the 13 studies in Osteochondritis Dissecans with a site in United States are open now. Recruiting first, the newest first:
Fin-Ceramica Faenza Spa · Sites in United States, Italy
Ages 18–60
Vericel Corporation · Sites in United States
Ages 10–17
University of Pennsylvania · Sites in United States
Duke University · Sites in United States
Ages 18–85
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 6 Osteochondritis Dissecans studies recruiting now, 2 set no upper age limit and 4 stop at 75 or younger; 5 take children under 18; none take healthy volunteers.
This study: 8 Years to 18 Years · all sexes · no healthy volunteers.
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13 studies; the count open now beside each. This study's row is marked.
First in 2010; this study’s year is marked. 1 started in 2013.
This study's enrollment of 91 is above the median of 45 across 17 interventional studies indexed under Osteochondritis Dissecans.
Median enrollment 75 across the 7 interventional studies, 130 across the 6 observational. Of the 6 that completed or were terminated, 1 (17%) have results posted.
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6 of 13 have an industry lead sponsor. The 10 most frequent:
Boston Children's Hospital is the lead sponsor of 608 studies on the registry; 147 are open to participants now.
Of its 32 completed or terminated interventional studies of FDA-regulated products, 19 (59%) have results posted.
Boston Children's Hospital has 1 study filed under Osteochondritis Dissecans — fewer than ten, so there is no comparison to draw.
1 of the studies in Osteochondritis Dissecans with a site in United States that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT02664337Duke UniversityConjoint Analysis of Patient Preferences in Joint Interventions | 2027-07 |
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Among the 13 studies in Osteochondritis Dissecans with a site in United States, from their registry updates:
Nothing recorded among them since 2026-09-25.
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The purpose of this study is to compare the functional, clinical and radiographic outcomes associated with trans-articular drilling versus retro-articular drilling, two commonly employed techniques of operative treatment for stable forms of juvenile osteochondritis dissecans (JOCD) lesions. This study also aims to better define the natural history of this condition in its most commonly identified pathological state (as a stable lesion) following surgical intervention by determining the rate of radiographic healing and any need for secondary surgery.
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Exclusion Criteria:
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Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
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Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Retro-articular drilling goes through the cortical margin of the affected condyle, thereby sparing the articular surface and physes.
Procedure: Retro-articular drilling
Trans-articular drilling penetrates the articular cartilage through multiple sites to create subchondral penetrations.
Procedure: Trans-articular drilling
* Drilling must be performed under AP and lateral fluoroscopic guidance, with no additional drilling in 'trans-articular', or intra-articular trans-condylar fashion. * Use a 0.045 K-wire for drilling. * Minimum of 8 wire passes per square centimeter with no maximum number of wire passes.
Also known as: antero-grade, extra-articular
* Drilling must be performed, under arthroscopic visualization, directly through the articular cartilage, with no additional drilling in 'retro-articular', 'extra-articular', or trans-condylar (through the intercondylar notch) * Use a 0.045 K-wire for drilling * A minimum 4 wire passes per square centimeter, with a maximum of 5 wire passes per square centimeter
Also known as: antero-grade, extra-articular
Physical functioning measured by the Pedi-IKDC (International Knee Documentation Committee) total score
Time frame: One year post-surgery
Activity level as measured by the Marx Activity Scale
Time frame: One year post-surgery
Physical functioning as measured by the Pedi-IKDC total score
Time frame: Two years post-surgery
Time to lesion healing
Lesion healing will be assessed by x-ray at multiple time points
Time frame: 3 months to 2 years post-surgery
Surgical complications
Inadvertent displacement of OCD fragment; damage to articular cartilage and physes
Time frame: 1 week to 1 year post-surgery
Ran from Jan 2013 to primary completion in Jul 2019, 78 months.
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This study is completed, as verified in Dec 2020. You cannot join it, but the record below documents what was studied.
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