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CompletedNCT01741584Updated Mar 16, 2016

Effects of Physical Activity on the Brain in Parkinson's Disease (PD)

An interventional study of stationary bike exercise and aerobic in Parkinson's Disease, sponsored by Charite University, Berlin, Germany. Completed at 1 site in Germany. Open to participants aged 35 Years to 80 Years. Per ClinicalTrials.gov, last updated 2016-03-16.

Sponsored by Charite University, Berlin, Germany · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Randomized
Ages
35 Years to 80 Years
Sex
All
01

Study summary

The aim of the study is to investigate whether exercise improves cognitive and motor functions in Parkinson's disease. To test this hypothesis, the researchers study general brain functions in subjects with PD during a 6-months exercise program.

02

Conditions studied

  • Parkinson's Disease

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03

In context

Parkinson Disease

4,487 studies on the registry are indexed under Parkinson Disease; 1,081 are open to participants now.

This study's planned enrollment of 20 is below the median of 40 across 3,293 interventional studies indexed under Parkinson Disease.

Browse Parkinson Disease studies →

Lead sponsor

Charite University, Berlin, Germany is the lead sponsor of 836 studies on the registry; 129 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
35 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • UPDRS \<15
  • L-DOPA responsive
  • \<5 yrs since diagnosis

Exclusion criteria

Exclusion Criteria:

  • severe other diseases
  • MMSE \< 26
  • treatment with psychiatric medication
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
20 participants (estimated)

Study arms

  • Experimental
    stationary bike exercise

    6 months of exercise (60% of anaerobic threshold)

    Behavioral: stationary bike exercise

  • Placebo comparator
    aerobic

    6 months of exercise \<30% anaerobic threshold

    Behavioral: aerobic

Interventions

  • Behavioralstationary bike exercise
  • Behavioralaerobic
06

What researchers measure

Primary outcomes

  1. UPDRS motor score

    Time frame: Prior to intervention and after 6 months of intervention

Secondary outcomes

  1. Functional/Structural brain changes

    Time frame: Prior to intervention and after 6 months of intervention

  2. Plasma biomarkers

    Time frame: Prior to intervention and after 6 months of intervention

  3. Cognitive Function based on neuropsychological test-performance

    Time frame: Prior to intervention and after 6 months of intervention

07

Study locations

1 site
  • Department of Neurology, Charité Universitätsmedizin Berlin
    Berlin, 10117, Germany
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 16, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01741584
Lead sponsor
Charite University, Berlin, Germany
Responsible party
Agnes Flöel (Prof. Dr. med. Agnes Floeel, Charite University, Berlin, Germany) — Principal investigator
First posted
Dec 5, 2012
Start date
Dec 2010
Primary completion
Sep 2014
Last update
Mar 16, 2016

Study contacts

Agnes Flöel, MD
principal investigator · Charite University, Berlin, Germany

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2016. You cannot join it, but the record below documents what was studied.

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