An observational study in Fasciitis, Necrotizing, sponsored by National Health Service, United Kingdom. Completed at 1 site in United Kingdom. Per ClinicalTrials.gov, last updated 2012-12-04.
Sponsored by National Health Service, United Kingdom · Observational
The investigators examined the hypothesis that serum lactate is raised in early necrotizing fasciitis to a much greater extent than in other differential diagnoses, such as severe cellulitis, and therefore provides a diagnostic indicator.
A prospective comparison of serum lactate levels at referral to the Plastic Surgery team to the 'gold standard' test of histology at initial surgical debridement, looking at 53 consecutive patients referred with suspected necrotizing fasciitis to a single surgeon at one institution between 2000 and 2010.
28 studies on the registry are indexed under Fasciitis, Necrotizing; 8 are open to participants now.
This study's enrollment of 53 is below the median of 152 across 16 observational studies indexed under Fasciitis, Necrotizing.
Browse Fasciitis, Necrotizing studies →National Health Service, United Kingdom is the lead sponsor of 13 studies on the registry; 1 is open to participants now.
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All patients referred to a single surgeon at one institution over 10 years (September 2000 - September 2010) with a suspected diagnosis of necrotizing fasciitis. Patients were followed for the duration of their hospital stay.
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Exclusion Criteria:
Histological evidence of necrotizing fasciitis at initial surgical debridement
A composite of those with no histological tissue necrosis at initial surgical debridement, and those clinically judged not to be a necrotizing infection who therefore did not undergo surgery.
Serum lactate level
Serum lactate level at initial referral to the plastic surgery team, as measured by arterial blood gas analysis (calibrated point-of-care testing). Levels compared between the group with confirmed histological necrosis at initial surgical debridement, versus those with no evidence of necrosis (a composite of those who did not undergo surgery as they were judged not to have necrotizing fasciitis, and those who did undergo surgery, but whose histology did not show tissue necrosis).
Time frame: At referral to the Plastic Surgery Team
This study is completed, as verified in Nov 2012. You cannot join it, but the record below documents what was studied.
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National Health Service, United Kingdom