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CompletedNCT01735331Updated Aug 7, 2015

Vascular Endothelial Growth Factor Levels at Hysteroscopic Biopsies Which Taken From Recurrent Pregnancy Loss

An observational study in Recurrent Pregnancy Loss Without Current Pregnancy, sponsored by Bagcilar Training and Research Hospital. Completed at 1 site in Turkey. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2015-08-07.

Sponsored by Bagcilar Training and Research Hospital · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
30
Ages
18 Years to 45 Years
Sex
Female
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Study summary

The aim of this study is determine vascular endothelial growth factor levels and angiogenesis/vascularity from hysteroscopic endometrial biopsies which taken from patients who has Recurrent Pregnancy Loss.The endometrial vascular endothelial growth factor levels will be measured by immunohistochemical staining methods due to office hysteroscopic endometrial biopsy after the menstruation at follicular phase of menstrual cycle.

Read the detailed description

This study is a prospective,observational,single-center study.Ethical approval was obtained from the Institutional Review Board.This study will be completed 30 patients with Habitual Abortus.

Endometrial vascular endothelial growth factor levels will be measured using Flk-1 / Kinase Domain Receptor / Vascular endothelial growth factor receptor-2, Ab-1 (Rabbit PAb), Vascular Endothelial Growth Factor (VEGF) Ab-7 (VG1), Cluster of Differentiation 34 (Endothelial Cell Marker) Ab-1 (QBEnd/10), Vascular endothelial growth factor receptor-1 (N-term) (FLT1) antibody kits. All assays will be performed according to the manufacturer's instructions.

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Conditions studied

  • Recurrent Pregnancy Loss Without Current Pregnancy

Keywords

  • Vascular endothelial growth factor, Recurrent Pregnancy Loss
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In context

Abortion, Spontaneous

320 studies on the registry are indexed under Abortion, Spontaneous; 53 are open to participants now.

This study's enrollment of 30 is below the median of 200 across 140 observational studies indexed under Abortion, Spontaneous.

Browse Abortion, Spontaneous studies →

Lead sponsor

Bagcilar Training and Research Hospital is the lead sponsor of 54 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
Female
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

The patients with Recurrent Pregnancy Loss

Inclusion criteria

  • Patients with Recurrent Pregnancy Loss who accept to join the study.

Exclusion criteria

Exclusion Criteria:

  • Patients whose age of \<18 and >45
  • Patients with have any pregnancy.
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Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
30 participants (actual)

Groups and cohorts

  • VEGF level

    VEGF level in hysteroscopic endometrial biopsy of the patients with recurrent pregnancy loss.

  • control group

    Patients with Abnormal Uterine Bleeding

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What researchers measure

Primary outcomes

  1. The primary outcome measure of this study is to determine endometrial vascular endothelial growth factor levels in patient with Recurrent Pregnancy Loss

    Time frame: 3 months

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Study locations

1 site
  • Bagcilar Training and Research Hospital
    Istanbul, Turkey
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 7, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01735331
Lead sponsor
Bagcilar Training and Research Hospital
Responsible party
Sponsor
First posted
Nov 28, 2012
Start date
Nov 2012
Primary completion
Aug 2013
Completion
Aug 2013
Last update
Aug 7, 2015

Study contacts

TANER A. USTA, M.D.
principal investigator · Bagcilar Training and Research Hospital,Istanbul,Turkey.

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2015. You cannot join it, but the record below documents what was studied.

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