An interventional study of Nefopam and low dose remifentanil in Patients Undergoing Laparoscopic Gastrectomy, sponsored by Yonsei University. Completed at 1 site in Korea, Republic of. Open to participants aged 20 Years to 65 Years. Per ClinicalTrials.gov, last updated 2014-02-19.
Sponsored by Yonsei University · Not applicable, Interventional, and Supportive care
Opioids has been reported to cause hyperalgesia. Opioid induced hyperalgesia (OIH) is defined as paradoxically lowering the threshold of pain after the exposure of opioid. Remifentanil is a short acting opioid that is commonly used during anesthesia and surgery. However, OIH was reported to occur after surgery when large amount of remifentanil was administered. On the other hand, nefopam is a centrally acting, non-opioid analgesic. Nefopam has been reported to have analgesic and anti-hyperalgesic effect.
The investigators hypothesized that nefopam administration could prevent OIH or reduce the severity of OIH. Therefore, the objective of the study is to find out the effect of nefopam on remifentanil induced hyperalgesia in patients undergoing laparoscopic abdominal surgery.
152 studies on the registry are indexed under Hyperalgesia; 13 are open to participants now.
This study's enrollment of 25 is below the median of 42 across 127 interventional studies indexed under Hyperalgesia.
Browse Hyperalgesia studies →Yonsei University is the lead sponsor of 1,387 studies on the registry; 232 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
receives 100 ml of 0.9% saline immediately after anesthesia induction and 0.05µg/kg/min of remifentanil during anesthesia.
Drug: low dose remifentanil
100 ml of 0.9% saline immediately after anesthesia induction and 0.3 µg/kg/min of remifentanil during anesthesia.
Drug: high dose remifentanil
20mg of nefopam mixed in 100 ml of 0.9% saline immediately after anesthesia induction and 0.3 µg/kg/min of remifentanil during anesthesia.
Drug: Nefopam
20 mg of Nefopam mixed in 100 ml of 0.9% saline IV immediately after induction of anesthesia.
100 ml of 0.9% saline immediately after anesthesia induction and 0.05µg/kg/min of remifentanil during anesthesia.
100 ml of 0.9% saline immediately after anesthesia induction and 0.3 µg/kg/min of remifentanil during anesthesia.
Hyperalgesic extent around surgical incision
The distance from the surgical incision to a point where patient does not feel pain when he gets stimuli with von Frey filament No.16 (122g/mm2).
Time frame: Postoperative 24 hr and 48 hr
This study is completed, as verified in Feb 2014. You cannot join it, but the record below documents what was studied.
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Yonsei University