CompletedNCT01732393Updated Dec 5, 2012

Effect of Quercetin in Prevention and Treatment of Oral Mucositis

A Phase 1/2 interventional study of oral quercetin capsules and Placebo in Chemotherapy Induced Oral Mucositis, sponsored by Mashhad University of Medical Sciences. Completed at 1 site in Iran, Islamic Republic of. Open to participants aged 15 Years to 40 Years. Per ClinicalTrials.gov, last updated 2012-12-05.

Sponsored by Mashhad University of Medical Sciences · Phase 1/2, Interventional, and Treatment

Phase: Phase 1/2
Study type: Interventional
Enrollment: 20
Allocation: Randomized
Ages: 15 Years to 40 Years
Sex: All

Study summary

The study aims to evaluate the effect of Quercetin (a natural flavonoid) on prevention of and treatment of chemotherapy-induced oral mucositis in patients with blood malignancies.

Conditions studied

Chemotherapy Induced Oral Mucositis

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Keywords

Quercetin
Chemotherapy
Mucositis
Hematologic Malignancies

In context

Mucositis

488 studies on the registry are indexed under Mucositis; 70 are open to participants now.

This study's enrollment of 20 is below the median of 50 across 394 interventional studies indexed under Mucositis.

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Lead sponsor

Mashhad University of Medical Sciences is the lead sponsor of 90 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 15 Years to 40 Years
Sexes eligible: All
Accepts healthy volunteers: No

Inclusion criteria

patient under chemotherapy
for a hematologic malignancy
the hematologist permits the trial on the patient
agreement of patient for participating in the trial

Exclusion criteria

Exclusion Criteria:

presence pf ANY oral lesion at the beginning of the trial
loss of follow up
use of digoxin and cyclosporine
patient death

Study design

Phase: Phase 1 / Phase 2
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel assignment
Masking: Quadruple (Participant, Care provider, Investigator, Outcomes assessor)
Enrollment: 20 participants (actual)

Study arms

Active comparator
oral quercetin capsules
Patients in the intervention group were administered two, 250 mg Quercetin capsules daily for 3 weeks
Drug: oral quercetin capsules
Placebo comparator
oral placebo capsules
Patients in the placebo group received two placebo capsules containing lactose .
Drug: Placebo

Interventions

Drugoral quercetin capsules
10 cases in case group and 10 cases in control group. Patients in the intervention group were administered two, 250 mg Quercetin capsules daily for 3 weeks. Patients in the placebo group received two placebo capsules containing lactose .Patients were examined every other day for evaluation of initiation and severity of oral mucositis.
DrugPlacebo

What researchers measure

Primary outcomes

lower grade of mucositis
grade of mucositis due to WHO criteria
Time frame: 3 weeks

Secondary outcomes

duration of mucositis
duration of mucositis due to Who criteria
Time frame: 3 weeks of study tiem span and after trial

Study locations

1 site

Oral Medicine Department of Mashhad dental School
MAshhad, Khorasan Razavi 91735-498, Iran, Islamic Republic of

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Dec 5, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT01732393
Lead sponsor: Mashhad University of Medical Sciences
Responsible party: Pegah Mosannen Mozafari (assistant professor of oral medicine, Mashhad University of Medical Sciences) — Principal investigator
First posted: Nov 22, 2012
Start date: Jan 2010
Primary completion: Oct 2011
Completion: Jan 2012
Last update: Dec 5, 2012

Study contacts

Pegah Mosannen Mozafari, assistant professor

study director · Mashhad University of Medical Sciences

Oversight

Data monitoring committee: Yes

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2012. You cannot join it, but the record below documents what was studied.

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