An observational study in Hypoactive Sexual Desire Disorder (HSDD), sponsored by University of British Columbia. Completed at 1 site in Canada. Open to female participants aged 19 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-10-17.
Sponsored by University of British Columbia · Observational
Women with Hypoactive sexual desire disorder (HSDD) have all measures of testosterone activity comparable to controls but lower levels of dehydroepiandrosterone (DHEA). Although DHEA is a precursor of testosterone it has other actions including involvement in the stress system. It is also linked to mood. This study focuses on measures of childhood stress, current mood and salivary stress hormones, in women with and without HSDD. We hypothesize that low levels of DHEA reflect dysfunction of the neuroendocrine stress response system involving the brain, pituitary and adrenal glands where DHEA is produced.
84 studies on the registry are indexed under Hypokinesia; 10 are open to participants now.
This study's enrollment of 324 is above the median of 253 across 16 observational studies indexed under Hypokinesia.
Browse Hypokinesia studies →University of British Columbia is the lead sponsor of 1,309 studies on the registry; 253 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 1 (17%) have results posted.
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Women with and without a diagnosis of Hypoactive Sexual Desire Disorder (HSDD).
Inclusion Criteria for HSDD Group:
Inclusion criteria for Control group:
Exclusion Criteria for both Control and HSDD groups:
Women with a diagnosis of Hypoactive Sexual Desire Disorder (HSDD).
Women without a diagnosis of Hypoactive Sexual Desire Disorder (HSDD).
DHEA levels
DHEA levels derived from saliva samples.
Time frame: Data is collected at 4 time points on 3 separate days
Cortisol levels
Cortisol levels derived from saliva samples.
Time frame: Data is collected at 4 time points on 3 separate days
Depression
Depression will be measured by the Beck Depression Inventory (Beck \& Beamesderfer, 1974)
Time frame: data is collected at single time point
Perceived stress
Perceived stress will be measured with the 10-item Perceived Stress Scale (Roberti, Harrington \& Storch 2006)
Time frame: data is collected at a single time point
Sexual function
Self-report sexual function will be measured with the Sexual Interest and Desire Inventory (Clayton et al. 2006))
Time frame: data is collected at a single time point
Relationship satisfaction
Relationship satisfaction will be measured with the Relationship Assessment Scale (Hendrick, 1988) and the Dyadic Adjustment Scale (Spanier, 1976)
Time frame: data is collected at a single time point
History of childhood trauma
History of childhood trauma will be determined with the Childhood Trauma Questionnaire (Bernstein \& Fink, 1995)
Time frame: dat is collected at a single timepoint
History of childhood sexual abuse
History of Childhood Sexual Abuse will be determined with the Childhood Sexual Abuse Measure (Finkelhor, 1979)
Time frame: data is collected at a single time point
PTSD symptoms
Presence and severity of post traumatic stress disorder symptoms will be determined through the Clinician-Administered PTSD Scale (Blake et al. 1998)
Time frame: data is collected at a single time point
This study is completed, as verified in May 2017. You cannot join it, but the record below documents what was studied.
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University of British Columbia