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CompletedNCT01682343Updated Sep 11, 2012

Effect of High-calcium Intake on Appetite, Insulinemia and Incretins

An interventional study of Calcium in Nutritional and Metabolic Diseases, sponsored by Northumbria University. Completed at 1 site in United Kingdom. Open to male participants, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-09-11.

Sponsored by Northumbria University · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
10
Allocation
Randomized
Sex
Male
01

Study summary

The purpose of this study is to investigate the appetite, insulin and incretin hormone responses to a high-calcium meal.

Read the detailed description

Participants will be provided with control and high-calcium meals. Insulin, appetite, glucagon-like peptide-1 and glucose-dependent insulinotropic peptide responses will be assessed, along with rates of substrate oxidation.

02

Conditions studied

  • Nutritional and Metabolic Diseases

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03

In context

Metabolic Diseases

997 studies on the registry are indexed under Metabolic Diseases; 234 are open to participants now.

This study's enrollment of 10 is below the median of 48 across 670 interventional studies indexed under Metabolic Diseases.

Browse Metabolic Diseases studies →

Lead sponsor

Northumbria University is the lead sponsor of 156 studies on the registry; 22 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

  • recreationally active
  • male

Exclusion criteria

Exclusion Criteria:

  • food intolerances/allergies
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double (Participant, Investigator)
Enrollment
10 participants (actual)

Study arms

  • Placebo comparator
    Placebo

    Breakfast consisting of milk-based porridge with a normal calcium content.

  • Experimental
    High-Calcium

    As control, but with a high-calcium content.

    Dietary Supplement: Calcium

Interventions

  • Dietary supplementCalcium

    Milk-calcium supplement

06

What researchers measure

Primary outcomes

  1. Subjective appetite ratings

    Subjective ratings of appetite assessed by visual analogue scales.

    Time frame: 3 hour

Secondary outcomes

  1. Serum insulin concentration

    2 hour area under the curve for serum insulin following breakfast consumption

    Time frame: 2 hour

  2. Plasma glucose-dependent insulinotropic peptide concentration

    2 hour area under the curve for plasma glucose-dependent insulinotropic peptide following breakfast consumption

    Time frame: 2 hour

  3. Plasma glucagon-like peptide-1 concentration

    2 hour area under the curve for plasma glucagon-like peptide-1 following breakfast consumption

    Time frame: 2 hour

Other outcomes

  1. Total fat oxidised during 60 min of exercise (g)

    Assessed by indirect calorimetry

    Time frame: 1 hour

07

Study locations

1 site
  • Northumbria University
    Newcastle upon Tyne, Tyne on Wear NE1 8ST, United Kingdom
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 11, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01682343
Lead sponsor
Northumbria University
Responsible party
Javier Gonzalez (PhD Student, Northumbria University) — Principal investigator
First posted
Sep 10, 2012
Start date
May 2012
Primary completion
Aug 2012
Completion
Aug 2012
Last update
Sep 11, 2012

Study contacts

Javier T Gonzalez, MRes
principal investigator · Northumbria University

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2012. You cannot join it, but the record below documents what was studied.

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