An observational study in Type 2 Diabetes, sponsored by Maastricht University Medical Center. Completed at 1 site in Netherlands. Open to male participants aged 45 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-10-12.
Sponsored by Maastricht University Medical Center · Observational
Inadequate suppression of intramuscular and adipose tissue lipolysis, and consequent excessive delivery of fatty acids to ectopic tissues (e.g. muscle, pancreas and liver) could play an important role in the development and exacerbating of insulin resistance. Therefore, the investigators propose to study the regulation of adipose tissue and skeletal muscle lipolysis, as well as further characterize the intracellular lipolytic pathways within these tissues, in obese normoglycaemic versus long-term diagnosed type 2 diabetic subjects.
9,589 studies on the registry are indexed under Diabetes Mellitus, Type 2; 1,332 are open to participants now.
This study's enrollment of 20 is below the median of 300 across 1,622 observational studies indexed under Diabetes Mellitus, Type 2.
Browse Diabetes Mellitus, Type 2 studies →Maastricht University Medical Center is the lead sponsor of 852 studies on the registry; 116 are open to participants now.
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Healthy normoglycemic men and type 2 diabetic men
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Normal glycaemic healthy control men, age between 45-65, BMI 25-35 kg/m2
Other: Hyperinsulinemic euglycemic clamp
Type 2 diabetic men, age 45-65 yrs, BMI 25-35, diagnosed \>5yrs and Hba1c 7-9%
Other: Hyperinsulinemic euglycemic clamp
Change from baseline in insulin sensitivity of adipose tissue and skeletal muscle lipolysis
Changes from baseline in glycerol (lactate, pyruvate and glucose) in tissue microdialysate during a 3 step euglycemic hyperinsulinemic clamp (8, 20 and 40mU of insulin), every step for 2h
Time frame: 8, 20 and 40 mU insulin (2 hours)
Baseline adipose tissue and skeletal muscle gene expression
gene expression of genes related to lipid, glucose metabolism, insulin signalling will be measured in baseline adipose tissue and skeletal muscle biopsies
Time frame: baseline
Baseline skeletal muscle lipid accumulation
Baseline skeletal muscle lipid accumulation is measured (TAG, DAG, Phospholipid and fatty acids)
Time frame: Baseline
The record gives a start of Jun 2007, a primary completion of Sep 2011 and a completion of Sep 2011. It does not say whether these dates are actual or estimated.
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This study is completed, as verified in Oct 2012. You cannot join it, but the record below documents what was studied.
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Maastricht University Medical Center →