A Phase 1 interventional study of Deep Brain Stimulation(DBS) and Capsulotomy in Anorexia, sponsored by Ruijin Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2012-09-05.
Sponsored by Ruijin Hospital · Phase 1, Interventional, and Treatment
Anorexia nervosa (AN) is a serious eating disorder mostly affecting adolescent girls and young adult women. There are many methods in the treatment of AN, such as family therapy, cognitive behavioral therapy, psychotherapy and so on. However, almost 50% of patients are refractory to all current medical treatment and never fully recover and the standardized mortality ratio over the first 10 years is about 10%. For treatment-refractory anorexia, stereotactic functional neurosurgery may be the better choice. Deep brain stimulation and capsulotomy are the most used methods which has been proved effective in obsessive and compulsive disorders, depression and other psychiatric disorders. Many case reports indicate that deep brain stimulation or capsulotomy may be effective in the treatment of AN. As there are some common pathways between AN and other psychiatric disorder. The investigators have a hypothesis that deep brain stimulation and capsulotomy may be promising methods in the treatment of AN.
Anorexia nervosa (AN) is a serious eating disorder mostly affecting adolescent girls and young adult women. Although the etiology of AN is still unclear, it is unanimous that social, genetic and psychological factors appear to be involved in the onset and maintenance of this disorder. There are many methods in the treatment of AN, such as family therapy, cognitive behavioral therapy, psychotherapy and so on. However, almost 50% of patients are refractory to all current medical treatment and never fully recover and the standardized mortality ratio over the first 10 years is about 10%. For treatment-refractory anorexia, stereotactic functional neurosurgery may be the better choice. Neurosurgery has been used in the treatment of mental diseases for more than fifty years. Deep brain stimulation and capsulotomy are the most used methods which has been proved effective in obsessive and compulsive disorders, depression and other psychiatric disorders. Many case reports indicate that deep brain stimulation or capsulotomy may be effective in the treatment of AN. As there are some common pathways between AN and other psychiatric disorders. The investigators have a hypothesis that deep brain stimulation and capsulotomy may be promising methods in the treatment of AN.
411 studies on the registry are indexed under Anorexia; 67 are open to participants now.
This study's planned enrollment of 48 is above the median of 41 across 287 interventional studies indexed under Anorexia.
Browse Anorexia studies →Ruijin Hospital is the lead sponsor of 635 studies on the registry; 359 are open to participants now.
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Treatment Resistance is defined by some or all of:
Exclusion Criteria:
Pregnancy
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Anorexia patients
Procedure: Deep Brain Stimulation(DBS) · Procedure: Capsulotomy
Deep Brain Stimulation(DBS)is a neurosurgical procedure which include the implantation of deep brain electrodes and the connect to an implantable pulse generator (IPG) that is implanted below the collarbone.
Anorexia Related Preoccupations and Rituals
Change from baseline in Anorexia Related Preoccupations and Rituals scores at 3 months, 6 months and 12 months
Time frame: April 2012-April 2014
This study is status unknown, as verified in Sep 2012. You cannot join it, but the record below documents what was studied.
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Ruijin Hospital