An interventional study of Hydrolyzed casein and Intact casein in Increased Energy Expenditure and Increased Satiety, sponsored by University of Copenhagen. Completed at 1 site in Denmark. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-07-29.
Sponsored by University of Copenhagen · Not applicable, Interventional, and Prevention
The primary aim is to examine and compare the effects of hydrolyzed casein (HC), intact casein (IC) and intact whey protein (IWP) on diet-induced thermogenesis (DIT). Furthermore, to study the effects on appetite regulation assessed by subjective appetite sensations, ad libitum energy intake and appetite regulating hormones.
Whey and casein differ in absorption and digestion rate, with whey being a fast protein and casein being a slow protein. When casein undergoes hydrolysis the absorption and digestion rates approaches the rates of whey. In the present study the importance of absorption rate and amino acid composition, in regards to energy expenditure and appetite regulation, will be examined. HC and IC have identical amino acid composition, but differ in absorption rate, whereas HC and IWP have similar absorption rates, but differ in amino acid composition. We hypothesize that consumption of HC will increase DIT and fat oxidation to a greater extend that IC. Moreover, that HC and IWP will increase satiety shortly after protein consumption, whereas IC will be more satiating after several hours.
The study is a controlled, randomized, 3-arm crossover study. It consists of three visits in a respiratory chamber separated by at least two weeks. 26 healthy, overweight and obese (BMI 27-35 kg/m2) young men will be enrolled and randomized to the order of the three protein supplements (HC, IC or IWP). At each visit protein supplements (containing either HC, IC or IWP) will be served as breakfast, lunch and dinner. Respiratory measures will be obtained over 24 hours and appetite will be assessed by visual analogue scales and appetite regulating hormones. Furthermore, ad libitum energy intake will be assessed.
University of Copenhagen is the lead sponsor of 450 studies on the registry; 61 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Hydrolyzed casein
Dietary Supplement: Hydrolyzed casein
Intact casein
Dietary Supplement: Intact casein
Intact whey protein
Dietary Supplement: Intact whey protein
30 g protein/supplement, 4 supplements/visit
Also known as: Hyvital casein CMA 500, Friesland Campina
30 g protein/supplement, 4 supplements/visit
Also known as: Miprodan 30, Arla Foods
30 g protein/supplement, 4 supplements/visit
Also known as: Lacprodan SP-9225 Instant, Arla Foods
Diet-induced thermogenesis
Time frame: 24 hours
Appetite assessed by visual analogue scales
Time frame: 24 hours
Appetite assessed by ad libitum energy intake
Time frame: 1 single meal
Appetite regulating hormones in plasma
Time frame: 4 hours
Components of respiratory measures (basal metabolic rate, sleeping metabolic rate and substrate oxidations)
Time frame: 24 hours
Differences in insulin, glucose and atrial natriuretic peptide
Time frame: 4 hours
Ad libitum energy intake assessed by 24 hour dietary records
Time frame: 24 hours
NMR-spectroscopy based metabonomics profiling of urin
Time frame: 24 hours
This study is completed, as verified in Jul 2013. You cannot join it, but the record below documents what was studied.
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University of Copenhagen