An interventional study of Retroflexion with the adult colonoscope. and Retroflexion with the pediatric colonoscope. in Colonic Neoplasms, sponsored by Medical College of Wisconsin. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 100 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-01-08.
Sponsored by Medical College of Wisconsin · Not applicable, Interventional, and Diagnostic
Screening colonoscopy has been shown to be less effective in preventing colorectal cancer in the proximal colon compared to the distal colon. Possible reasons for this include bowel preparation often being worse in the proximal colon as well as flat depressed lesions being more common in the proximal colon.
Retroflexion is commonly regarded as standard practice in the rectum, but retroflexion in the proximal colon is not currently routinely performed due to concerns of perforation and possibly because of the increased time required.
Proximal colon retroflexion has been shown to be safe and effective without any complications, but data regarding ability to retroflex with certain types of colonoscopes is limited. Endoscopists interchangeably use standard adult colonoscopes or pediatric colonoscopes. Studies have not been performed to comparatively evaluate the success rates of standard adult and pediatric colonoscopes and whether either type of instrument confers a greater polyp detection rate.
1,432 studies on the registry are indexed under Colonic Neoplasms; 357 are open to participants now.
Browse Colonic Neoplasms studies →Medical College of Wisconsin is the lead sponsor of 540 studies on the registry; 120 are open to participants now.
Of its 71 completed or terminated interventional studies of FDA-regulated products, 56 (79%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Use of the adult colonoscope.
Procedure: Retroflexion with the adult colonoscope.
Use of the pediatric colonoscope.
Procedure: Retroflexion with the pediatric colonoscope.
Percentage of cases in which right-sided retroflexion is successful with the adult and pediatric colonoscopes.
Time frame: After 50% and 100% of patient enrollment is complete.
Adenoma detection rate in forward and retroflexed views.
Time frame: After 50% and 100% of patient enrollment is complete.
Reasons for failure of retroflexion.
This will be assessed as a yes/no variable. In addition, the specific reasons that the endoscopist could not retroflex the colonoscope in the right colon will assessed, such as the colonoscope not being able to be advanced to the cecum, small diameter of the right colon, too much resistance encountered when attempting retroflexion that the endoscopist does not feel comfortable with, etc.
Time frame: After 50% and 100% of patient enrollment is complete.
This study is withdrawn, as verified in Jan 2016. You cannot join it, but the record below documents what was studied.
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Medical College of Wisconsin