An interventional study of Antioxidant and Prostaglandin inhibitor (Ibuprophen) in Ischemic Reperfusion Injury, sponsored by University of Essex. Completed at 1 site in United Kingdom. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-05-12.
Sponsored by University of Essex · Not applicable, Interventional, and Basic science
The purposes of this study are two-fold. The first purpose is to determine the effect of taking vitamins on the recovery of an artery (blood vessel) following an induced temporary injury. The second purpose is to determine whether a specific vasodilator is less abundant after the injury and whether this contributes to increased constriction or after the injury. Finally, does vitamin consumption have an effect on the recovery from the injury if one of the substances in the blood that causes vessels to enlarge (dilate) is stopped?
University of Essex is the lead sponsor of 8 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
Control trial to determine the impact of the ischemic injury on vascular function without intervention
Trial to determine the impact of an antioxidant load before the ischemic injury on vascular function recovery
Dietary Supplement: Antioxidant
Trial to determine the impact of a non-selective prostaglandin inhibitor before the ischemic injury on vascular function recovery
Drug: Prostaglandin inhibitor (Ibuprophen)
Trial to determine the impact of an antioxidant load and prostaglandin inhibitor before the ischemic injury on vascular function recovery
Dietary Supplement: Antioxidant · Drug: Prostaglandin inhibitor (Ibuprophen)
Also known as: ibuprofen
Change in flow mediated dilation
Flow mediated dilation is a measure of vascular function and is measured as the outcome before and after an injury to the inner lining of the artery.
Time frame: Change from baseline at 15 minutes after ischemia-reperfusion injury
Change in low flow mediated constriction
low flow mediated constriction is a measure of vascular function and is measured to establish the impact of a vascular injury
Time frame: Change from baseline at 15 minutes after ischemia-reperfusion injury
This study is completed, as verified in May 2017. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Antioxidants · Ibuprofen
University of Essex