An interventional study of Diet A and Diet B in Obesity, sponsored by Pennington Biomedical Research Center. Completed at 1 site in United States. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-01-18.
Sponsored by Pennington Biomedical Research Center · Not applicable and Interventional
The purpose of this trial is to examine the metabolic and behavioral effects of a positive energy balance induced by adding food to the usual level of activity.
It is hypothesized that: 1) food intake will not differ significantly after 2 days of positive energy balance induced by a high carbohydrate vs. high fat diet when both diets are low in energy density, and 2) food intake will be higher after a positive energy balance induced by a high fat/high energy dense diet vs. a high fat/low energy dense diet.
The purpose of this trial is to examine the metabolic and behavioral effects of a positive energy balance induced by adding food to the usual level of activity. During this study, we will induce a positive energy balance for two days by increasing food intake to 140% of baseline energy requirements and keeping energy expenditure constant. The following three diets, which vary in dietary fat and energy density (kcal/g), will be used to induce the positive energy balance in a within subjects or cross over design: 1) high fat/high energy density, 2) high fat/low energy density, and 3) high carbohydrate/low energy density. Food intake and activity will be measured for 4 days after each diet to quantify the response to positive energy balance and manipulation of dietary fat and energy density.
Pennington Biomedical Research Center is the lead sponsor of 277 studies on the registry; 29 are open to participants now.
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Exclusion Criteria:
Low Fat High Energy Density (1.6 kcal/g)-50% Fat, 35% Carbohydrate, and 15% Protein
Other: Diet A · Other: Diet B · Other: Diet C
High Fat Low Energy Density (1.05 kcal/g)-50% Fat, 35% Carbohydrate, and 15% Protein
Other: Diet A · Other: Diet B · Other: Diet C
High Carbohydrate Low Energy Density (1.05 kcal/g)-20% Fat, 65% Carbohydrate, 15% Protein
Other: Diet A · Other: Diet B · Other: Diet C
Dietary
Also known as: Low Fat High Energy Density (1.6 kcal/g)-50% Fat, 35% Carbohydrate, and 15% Protein
Dietary
Also known as: High Fat Low Energy Density (1.05 kcal/g)-50% Fat, 35% Carbohydrate, and 15% Protein
Dietary
Also known as: High Carbohydrate Low Energy Density (1.05 kcal/g)-20% Fat, 65% Carbohydrate, 15% Protein
Energy Intake
Food intake will be measured for 4 days after positive energy balance by directly weighing foods before and after ad libitum lunch and dinner. All food intake testes will occur while the participant resides in the inpatient unit.
Time frame: 4 days following the 2 day overfeeding
Energy Expenditure
Armbands were worn by participants throughout the protocol to quantify changes in activity levels and energy expenditure to positive energy balance.
Time frame: 4 days following 2 days of overfeeding
This study is completed, as verified in Jan 2016. You cannot join it, but the record below documents what was studied.
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Pennington Biomedical Research Center