An observational study in Advanced Heart Failure and Left Ventrucular Assist Device, sponsored by University of Minnesota. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2014-12-18.
Sponsored by University of Minnesota · Observational
An observational study of neuron specific enolase, as a marker of reperfusion injury, in LVAD recipients before and following VAD implantation.
Patients eligible for left ventricular assist device (LVAD) typically have severe heart failure, which is characterized by poor cardiac output. The relatively abrupt increase in cardiac output that follows implant of a LVAD may cause reperfusion injury. Furthermore, selected patients may have particularly severe consequences of such injury, including refractory acidosis and vasoplegia. Neuron specific enolase (NSE) has been established as a biomarker of reperfusion injury. We hypothesize that changes in NSE following LVAD will be greater than the changes in NSE noted in a control population of patients undergoing non-VAD cardiac surgery.
5,701 studies on the registry are indexed under Heart Failure; 1,220 are open to participants now.
This study's enrollment of 15 is below the median of 200 across 1,679 observational studies indexed under Heart Failure.
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Cardiovascular Surgical candidates from outpatient cardiology clinic or inpatient service.
Group 1 - Pre-VAD implantation patients
Exclusion Criteria:
18 years and older Planning to undergo VAD implantation
18 years or older Planning to undergo valve or coronary bypass surgery
Neuron-Specific Enolase
Time frame: Pre and post-surgery
This study is completed, as verified in Dec 2014. You cannot join it, but the record below documents what was studied.
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University of Minnesota