A Phase 1 interventional study of Cogntive Activation Training and Waitlist Control / Home-based training in Mild Cognitive Impairment, sponsored by Rotman Research Institute at Baycrest. Status unknown at 1 site in Canada. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2012-07-16.
Sponsored by Rotman Research Institute at Baycrest · Phase 1, Interventional, and Treatment
Mild cognitive impairment (MCI) describes an initial phase of cognitive decline, usually among older adults, in which a person notices a decline in attention or memory, and performs worse than normal on cognitive tests of such. People with MCI are more likely to develop Alzheimer's disease or related dementia than others their same age, and so MCI is thought of as an early warning sign of progressive cognitive decline.
While some forms of MCI may be brought about by purely genetic causes, other cases may be due to a withdrawal of cognitive engagement with the world. In these cases, a rigorous program of cognitive training may be beneficial, halting or reversing symptom progression.
The current study will evaluate a multifaceted cognitive activation program on older adults with MCI. This group program is intensive, running for 10 weeks, 3 times per week, for a total of 100 hours of training. Training consists of meditation exercises for broad attention activation, Tai Chi exercises to integrate cognition with body awareness, and cognitive training through computerized attention, memory, and problem solving exercise.
Subjective impressions and objective measures of cognitive ability will be measured before and after the intervention. The investigators will also examine effects on mood and levels of daily function. Results will be compared to a waitlisted control group. The control group will subsequently be entered into a home-based version of the program for 10 weeks, with assessment before and after training, to look at the importance of the group meeting dynamic in promoting cognitive change.
3,930 studies on the registry are indexed under Cognitive Dysfunction; 1,114 are open to participants now.
This study's planned enrollment of 30 is below the median of 64 across 2,855 interventional studies indexed under Cognitive Dysfunction.
Browse Cognitive Dysfunction studies →Rotman Research Institute at Baycrest is the lead sponsor of 11 studies on the registry; 4 are open to participants now.
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Exclusion Criteria:
This group will serve as a waitlist control group while the active group is performing training. Following assessment at the end of the active group period, this group will begin home-based training and will be assessed at the end of that 10 week period.
Behavioral: Waitlist Control / Home-based training
This group will attend the 3/week group intervention meetings over 10 weeks.
Behavioral: Cogntive Activation Training
Mindfulness-based stress reduction - 30 minutes / class x 3 classes / week; optional home practice Tai Chi - 30 minutes / class x 3 classes / week; optional home practice Computer-based cognitive training - 20 minutes / class x 3 classes / week; optional home practice
Also known as: Computer-based cognitive training is provided by Lumosity
Computer-based cognitive training - 20 minutes / day Daily walking - 20 minutes / day Biofeedback relaxation Training - 20 minutes / day
Also known as: Computer-based cognitive training is provided by Lumosity, Biofeedback relaxation training is provided by HeartMath
Processing Speed
Processing speed on computerized cognitive task.
Time frame: Before and After Intervention
Memory
Tests of immediate recall and delayed recall, recognition, and familiarity.
Time frame: Before and After Intervention
Executive Function
Tests of inhibition, task switching, and problem solving.
Time frame: Before and After Intervention
Attention / Working Memory
Working memory measures such as digit span, selection of targets among distractors, etc.
Time frame: Before and after intervention
Mood and Well-being
Tests of dysphoric affect and subjective quality of life
Time frame: Before and after intervention
Daily Function
Tests of instrumental activities of daily living
Time frame: Before and after intervention
This study is status unknown, as verified in Jul 2012. You cannot join it, but the record below documents what was studied.
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Rotman Research Institute at Baycrest