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CompletedNCT01638351Updated Nov 16, 2012

Resistance Training in Diabetic Elder Patients

An interventional study of Resistance exercise and Usual care in Diabetes Mellitus, Type 2, sponsored by National Taiwan University Hospital. Completed at 1 site in Taiwan. Open to participants aged 65 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-11-16.

Sponsored by National Taiwan University Hospital · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
49
Allocation
Randomized
Ages
65 Years to 80 Years
Sex
All
01

Study summary

The purpose of this study is to investigate the effect of a 12-week progressive resistance training program on the skeletal muscle function, glycemic control, functional capacity, and quality of life in the elderly with type 2 diabetes mellitus.

02

Conditions studied

  • Diabetes Mellitus, Type 2

Keywords

  • Diabetes mellitus
  • Resistance exercise
  • Elderly
  • Skeletal muscle dysfunction
  • Metabolomics
03

In context

Diabetes Mellitus, Type 2

9,589 studies on the registry are indexed under Diabetes Mellitus, Type 2; 1,332 are open to participants now.

This study's enrollment of 49 is below the median of 81 across 7,713 interventional studies indexed under Diabetes Mellitus, Type 2.

Browse Diabetes Mellitus, Type 2 studies →

Lead sponsor

National Taiwan University Hospital is the lead sponsor of 2,608 studies on the registry; 573 are open to participants now.

Of its 11 completed or terminated interventional studies of FDA-regulated products, 2 (18%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
65 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • 65 years old or older
  • no clinical diagnosis of cardiovascular disease
  • patients with or without type 2 diabetes mellitus

Exclusion criteria

Exclusion Criteria:

  • glycated hemoglobin > 10%
  • pulmonary disease
  • cancer
  • cognitive dysfunction
  • any neurological or musculoskeletal disease that will affect exercise performance
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
49 participants (actual)

Study arms

  • Active comparator
    Usual care

    Participants in this arm will receive a brochure specific for type 2 diabetes mellitus about the general principles of exercise, nutrition, and diet. They are asked to maintain their activity level.

    Behavioral: Usual care

  • Experimental
    Resistance exercise

    Progressive resistance training, 3 times a week for 12 weeks

    Behavioral: Resistance exercise

Interventions

  • BehavioralResistance exercise

    Progressive resistance exercise training, 3 times a week for 12 weeks.

  • BehavioralUsual care

    Participants in this arm will receive a brochure specific for type 2 diabetes mellitus about the general principles of exercise, nutrition, and diet. They are asked to maintain their activity level.

06

What researchers measure

Primary outcomes

  1. Maximal muscle strength

    This outcome measure includes upper and lower body maximal muscle strength.

    Time frame: Twelve weeks

Secondary outcomes

  1. Physical body function

    This outcome will be assessed by one minute sit-to-stand test and timed "Up and Go" test.

    Time frame: Twelve weeks

  2. Quality of life

    This outcome measure will be assessed by the diabetes-specific questionnaire.

    Time frame: Twelve weeks

  3. Waist circumference

    Time frame: Twelve weeks

  4. Body mass index

    This outcome measure includes the measurements of body height and body weight.

    Time frame: Twelve weeks

  5. Functional capacity

    Peak oxygen consumption will be determined by graded exercise test to assess functional capacity.

    Time frame: Twelve weeks

  6. Blood biochemical parameters

    This outcome measure includes the analysis of fasting glucose, glycated hemoglobin, lipid profile, C-reactive protein, and related metabolites.

    Time frame: Twevle weeks

  7. Muscle oxygenation

    Muscle oxygenation will be assessed during exercise

    Time frame: Twelve weeks

07

Study locations

1 site
  • National Taiwan University Hospital
    Taipei, 100, Taiwan
08

References and documents

Publications

  • Castaneda C, Layne JE, Munoz-Orians L, Gordon PL, Walsmith J, Foldvari M, Roubenoff R, Tucker KL, Nelson ME. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care. 2002 Dec;25(12):2335-41. doi: 10.2337/diacare.25.12.2335. PubMed 12453982 ↗
  • Dunstan DW, Daly RM, Owen N, Jolley D, De Courten M, Shaw J, Zimmet P. High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care. 2002 Oct;25(10):1729-36. doi: 10.2337/diacare.25.10.1729. PubMed 12351469 ↗
  • Brandon LJ, Gaasch DA, Boyette LW, Lloyd AM. Effects of long-term resistive training on mobility and strength in older adults with diabetes. J Gerontol A Biol Sci Med Sci. 2003 Aug;58(8):740-5. doi: 10.1093/gerona/58.8.m740. PubMed 12902533 ↗
  • Cheung NW, Cinnadaio N, Russo M, Marek S. A pilot randomised controlled trial of resistance exercise bands in the management of sedentary subjects with type 2 diabetes. Diabetes Res Clin Pract. 2009 Mar;83(3):e68-71. doi: 10.1016/j.diabres.2008.12.009. Epub 2009 Jan 20. PubMed 19157617 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 16, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01638351
Responsible party
Sponsor
First posted
Jul 11, 2012
Start date
Dec 2011
Primary completion
Oct 2012
Completion
Oct 2012
Last update
Nov 16, 2012

Study contacts

Ying-Tai Wu, Ph.D.
study chair · School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University (R.O.C.)

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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