An observational study in Asthma, sponsored by Singapore General Hospital. Recruiting at 1 site in Singapore. Open to participants aged 21 Years to 80 Years. Per ClinicalTrials.gov, last updated 2021-07-28.
Sponsored by Singapore General Hospital · Observational
Asthma is a heterogenous disease. Different patients have different presentations, course of disease and response to treatment.
The investigators would like to study our population of more severe asthma and find out about their profile - demographic, clinical and inflammatory.
Asthma is a heterogeneous disorder presenting with many phenotypes. Most asthmatics have mild to moderate disease. However, 5-20% of asthmatics belong to the "Difficult-to-treat" or more severe group and they account for 50-80% of asthma health care costs. In a tertiary hospital like Singapore General Hospital, most of our asthmatics belong to the more severe group. They have more frequent healthcare visits, hospitalizations, medication use and higher risks of death.
There is currently no local data on the phenotypic profile of our patients. Asthma phenotypes which have been identified include those related to triggers ( eg. drugs such as aspirin or NSAIDS, environmental allergen, occupational allergens or irritants, exercise) or clinical physiological phenotypes ( eg. severity-defined, exacerbation-prone, chronic airflow limitation, steroid-resistant, age -of -onset) or inflammatory phenotypes ( eg. eosinophilic, neutrophilic, pauci granulocytic, mixed). With better understanding of their phenotypes, treatment can then be individually tailored to improve their asthma control and reduce future risks.
We aim to improve the understanding of this group of asthmatics such that better treatment approaches can be developed in the future. This is not a clinical trial. Its purpose is to gather information ranging from demographic data, medical history to responses to simple routine questions, to lung function, inflammation, allergy and blood testing results. The data are analyzed to improve our understanding of the clinical and inflammatory phenotypes ( or profiles) in this group of patients.
3,921 studies on the registry are indexed under Asthma; 507 are open to participants now.
This study's planned enrollment of 1,000 is above the median of 150 across 970 observational studies indexed under Asthma.
Browse Asthma studies →Singapore General Hospital is the lead sponsor of 266 studies on the registry; 57 are open to participants now.
Of its 8 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Respiratory or severe asthma clinic
Inclusion Criteria:
Annual exacerbation rates
Annual exacerbation rates
Time frame: Through study completion, an average of 1 year
Symptom control
Symptom control using Asthma Control Test
Time frame: Through study completion, an average of 1 year
Plan to share: No
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Singapore General Hospital