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CompletedNCT01619345Updated Feb 23, 2015

Pharmacoscintigraphic Investigation of NN9924 in Healthy Male Subjects

A Phase 1 interventional study of semaglutide in Diabetes and Healthy, sponsored by Novo Nordisk A/S. Completed at 1 site in United Kingdom. Open to male participants aged 18 Years to 64 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-02-23.

Sponsored by Novo Nordisk A/S · Phase 1, Interventional, and Treatment

Phase
Phase 1
Study type
Interventional
Enrollment
27
Allocation
Randomized
Ages
18 Years to 64 Years
Sex
Male
01

Study summary

This trial is conducted in Europe. The aim of this trial is to investigate whether the volume of water administered with NN9924 affects the anatomical location (stomach or proximal small bowel) of tablet erosion.

02

Conditions studied

  • Diabetes
  • Healthy

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03

In context

Diabetes Mellitus

11,089 studies on the registry are indexed under Diabetes Mellitus; 1,319 are open to participants now.

This study's enrollment of 27 is below the median of 80 across 8,491 interventional studies indexed under Diabetes Mellitus.

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Lead sponsor

Novo Nordisk A/S is the lead sponsor of 1,400 studies on the registry; 102 are open to participants now.

Of its 204 completed or terminated interventional studies of FDA-regulated products, 98 (48%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 64 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Good general health
  • Body mass index (BMI) of 18.5-30.0 kg/m\^2 (both inclusive)

Exclusion criteria

Exclusion Criteria:

  • Males who are not willing to use two acceptable forms of highly effective contraception
  • Participation in another clinical trial within 90 days
  • Any chronic disorder or severe disease
  • Use of GLP-1 (glucagon-like peptide-1) agonists within 3 months preceding dosing
  • Subjects who are smokers
  • Subjects who have donated any blood or plasma in the past month or in excess of 500 mL within the 12 weeks preceding screening
05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
27 participants (actual)

Study arms

  • Experimental
    Period 1: NN9924 with 50 mL water

    Drug: semaglutide

  • Experimental
    Period 2: NN9924 with 240 mL water

    Drug: semaglutide

Interventions

  • Subjects will be treated with two single doses of 10 mg semaglutide in a tablet. Dosing will be done on 2 dosing visits separated by 4 to 6 weeks.

    Also known as: NN9924

06

What researchers measure

Primary outcomes

  1. Anatomical location (stomach or proximal small bowel) of tablet at complete tablet erosion (CTE)

    Time frame: Assessed 0-4 hours post dose

Secondary outcomes

  1. Area under the NN9924 concentration curve

    Time frame: From time 0-24 hours

  2. Anatomical location of initial tablet erosion (ITE)

    Time frame: Assessed 0-4 hours post dose

  3. Time to ITE

    Time frame: Assessed 0-4 hours post dose

  4. Time to CTE

    Time frame: Assessed 0-4 hours post dose

07

Study locations

1 site
  • Nottingham, NG11 6JS, United Kingdom
08

References and documents

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 23, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01619345
Lead sponsor
Novo Nordisk A/S
Responsible party
Sponsor
First posted
Jun 14, 2012
Start date
Jun 2012
Primary completion
Aug 2012
Completion
Aug 2012
Last update
Feb 23, 2015

Study contacts

Global Clinical Registry (GCR, 1452)
study director · Novo Nordisk A/S

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Feb 2015. You cannot join it, but the record below documents what was studied.

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