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CompletedNCT01610986LactExUpdated Jun 4, 2014

Effects of Glucose-fructose Drinks During Training on Lactate Transport

An interventional study of Glucose-fructose and Water in Normal Physiology on Healthy Subjects, sponsored by University of Lausanne. Completed at 1 site in Switzerland. Open to male participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-06-04.

Sponsored by University of Lausanne · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
17
Allocation
Randomized
Ages
18 Years to 30 Years
Sex
Male
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Study summary

The purpose of this study is to determine whether glucose-fructose intake during training increases lactate transport and oxidation and improve endurance performance.

Read the detailed description

The study will enroll 24 healthy male volunteers. After baseline assessment of lactate transport and endurance performance, subjects will be randomized to either a 3-week intervention arm in which they will train with glucose-fructose intake during training, or to a control arm (water during training). After this 3-week intervention, lactate transport and endurance performance will be assessed again.

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Conditions studied

  • Normal Physiology on Healthy Subjects

Keywords

  • Fructose
  • Exercise
  • Lactic acid
  • Monocarboxylic Acid Transporters
03

In context

Lead sponsor

University of Lausanne is the lead sponsor of 54 studies on the registry; 5 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 30 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

  • healthy
  • age between 18 and 30 years
  • sedentary
  • BMI between 19 and 25
  • blood pressure lower than 140/90 mmHg

Exclusion criteria

Exclusion Criteria:

  • smoking
  • consumption of more than 10g alcohol per day
  • cardiovascular history
  • electrographic abnormalities at rest
  • consumption of more than one can of soda per day or more than 60g sugars per day
  • any current drug treatment
  • consumption of drugs or illicit substances
  • diabetes mellitus
  • vegetarian
  • food intolerance
  • blood donation or participation to another study \<3 months before study inclusion
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Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
17 participants (actual)

Study arms

  • Experimental
    Glucose-fructose

    Participants will take glucose-fructose drinks during training sessions

    Dietary Supplement: Glucose-fructose

  • Experimental
    Water

    Participants will take only water during training sessions

    Dietary Supplement: Water

Interventions

  • Dietary supplementGlucose-fructose

    0.8 g/h glucose and 0.5 g/h fructose during training

  • Dietary supplementWater

    Only water intake during training

06

What researchers measure

Primary outcomes

  1. Change in lactate transport

    Measurement of lactate production, utilization, oxidation and clearance during a 90 min cycling exercise at 50% VO2 max (measured with 13C-lactate)

    Time frame: At baseline (before training) and after the 3-week training protocol

Secondary outcomes

  1. Change in muscle monocarboxylate transporters (MCTs) expression and protein content

    MCTs expression (mRNA) and protein content after muscle biopsy

    Time frame: At baseline (before training) and after the 3-week training protocol

07

Study locations

1 site
  • University of Lausanne
    Lausanne, Vaud 1005, Switzerland
08

References and documents

Publications

  • Lecoultre V, Benoit R, Carrel G, Schutz Y, Millet GP, Tappy L, Schneiter P. Fructose and glucose co-ingestion during prolonged exercise increases lactate and glucose fluxes and oxidation compared with an equimolar intake of glucose. Am J Clin Nutr. 2010 Nov;92(5):1071-9. doi: 10.3945/ajcn.2010.29566. Epub 2010 Sep 8. PubMed 20826630 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 4, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01610986
Lead sponsor
University of Lausanne
Collaborators
Centre Hospitalier Universitaire Vaudois
Responsible party
Luc Tappy, MD (Professor of Physiology, University of Lausanne) — Principal investigator
First posted
Jun 4, 2012
Start date
May 2012
Primary completion
Mar 2014
Completion
Mar 2014
Last update
Jun 4, 2014

Study contacts

Luc Tappy, Pr
principal investigator · University of Lausanne

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2014. You cannot join it, but the record below documents what was studied.

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