A Phase 1 interventional study of Oxytocin in Healthy Male Volunteers, sponsored by University Hospital, Bonn. Completed at 1 site in Germany. Open to male participants aged 20 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-12-03.
Sponsored by University Hospital, Bonn · Phase 1, Interventional, and Basic science
The purpose of this study is to determine whether oxytocin influences memory of social stimuli and reaction to social stimuli. Furthermore the investigators explore the effect of oxytocin receptor (OXTR) polymorphism in terms of behavioral and neural responses to social stimuli.
The prevailing view of OXT as a key facilitator of prosocial behaviors has been highly influenced by a plethora of studies in healthy volunteers, which demonstrated increased interpersonal trust, generosity, social learning/empathy and positively biased social stimulus processing as a result of OXT treatment. However, this interpretation is challenged by observations that OXT also promotes envy and schadenfreude (gloating), ethno-centrism (including prejudice, xenophobia, and racial bias), and defensive aggression towards outsiders.We investigate the neural correlates of emotion perception and subsequent memory effects of aversive and neutral stimuli. Tthe oxytocin effect on personal space is questioned. Additionally the effect of OXTR polymorphism regarding behavioral and neural response is explored.
University Hospital, Bonn is the lead sponsor of 154 studies on the registry; 30 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
one application of 24 IU oxytocin per volunteer
Drug: Oxytocin
sodium chloride solution, intranasal application, 3 puffs per nostril one application per volunteer
Drug: Oxytocin
intranasal administration, 24 IU oxytocin; ; 3 puffs per nostril, each with 4 IU OXT
Also known as: Oxytocin: Syntocinon-Spray, Novartis
neural correlates of emotion perception and subsequent memory effects of aversive and neutral stimuli
MRI data are analyzed using SPM8 (Wellcome Trust Centre for Neuroimaging, London, UK). In the first level analysis the following conditions are modeled: 'neutral: subsequently remembered', 'neutral: subsequently forgotten', 'aversive: subsequently remembered', and 'aversive: subsequently forgotten'.
Time frame: two years
the effect of oxytocin receptor (OXTR) polymorphism in terms of behavioral and neural responses to social stimuli
behavioral social testing, fMRI analysis using SPM8, OXTR genotyping
Time frame: two years
The oxytocin effect on social behavior e.g. personal space is questioned
behavioral testing e.g. personal space
Time frame: two years
This study is completed, as verified in Dec 2014. You cannot join it, but the record below documents what was studied.
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University Hospital, Bonn