An observational study in Surgical Trauma, sponsored by Martin Angst. Completed at 1 site in United States. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2013-10-30.
Sponsored by Martin Angst · Observational
Surgical trauma triggers a massive inflammatory response. Over time, both the innate and adaptive branches of the immune system are affected by surgical trauma. The purpose of this study to characterize the cellular and molecular mechanisms immune response to surgical trauma. Additionally, detailed information about patients' recovery profile will be recorded over a period of 6 weeks, with the eventual goal of linking immune responses to recovery profiles.
Martin Angst is the lead sponsor of 8 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients undergoing primary hip replacement.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Mass cytometry of immune signaling events
The primary molecular outcome is the fold change in phosphorylation of signaling proteins.
Time frame: Blood samples for mass cytometry will be drawn at baseline, 1 hour post-op, 24 hours post-op, 3 days post-op, and 6 weeks post-op.
Surgical Recovery Scale (SRS)
The surgical recovery scale is a validated questionnaire yielding a numerical score and assessing postoperative recovery.
Time frame: Data will be collected at baseline, daily through the hospitalization, and every 3 days for 6 weeks.
Western Ontario and McMaster Universities Arthritis Index (WOMAC)
Western Ontario and McMaster Universities Arthritis Index is a validated questionnaires yielding a numerical score and assessing functional status and pain in patients suffering from osteoarthritis of the hip.
Time frame: Data will be collected at baseline, daily through the hospitalization, and every 3 days for 6 weeks.
Plasma cytokines
The plasma concentration of plasma cytokines and chemokines will be measured with aid of a large protein array.
Time frame: Blood samples will be drawn at baseline, 1 hour post-op, 24 hours post-op, 3 days post-op, and 6 weeks post-op.
This study is completed, as verified in Oct 2013. You cannot join it, but the record below documents what was studied.
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Martin Angst