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CompletedNCT01572961MICROTECUpdated Feb 12, 2016

Microvascular Function Assessment in Healthy Subjects

An interventional study of acetylsalicilic acids (Aspirin) and Placebo in Physiology of Microvascular Skin, sponsored by University Hospital, Angers. Completed at 1 site in France. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-02-12.

Sponsored by University Hospital, Angers · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
16
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

Current stimulation induces microvascular dilation in human skin. The investigators aimed to study (1) whether the current vasodilation is amplified after two segmental current stimulation as compared to one stimulation; (2) whether this amplification relies on prostaglandin-sensitive mechanisms. A double-blind randomized placebo-controlled crossover trial is conducted in Angers, France.

02

Conditions studied

  • Physiology of Microvascular Skin

Keywords

  • Laser Doppler flowmetry, skin, microcirculation
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In context

Lead sponsor

University Hospital, Angers is the lead sponsor of 464 studies on the registry; 116 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Age > or equal to 18 years old
  • Healthy subjects

Exclusion criteria

Exclusion Criteria:

  • Aspirin allergy
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Triple (Participant, Care provider, Investigator)
Enrollment
16 participants (actual)

Study arms

  • Active comparator
    Aspirin

    Aspirin

    Drug: acetylsalicilic acids (Aspirin)

  • Placebo comparator
    Placebo

    Placebo

    Drug: Placebo

Interventions

  • Drugacetylsalicilic acids (Aspirin)

    single oral dose of 1g.

    Also known as: Aspegic 1000mg, sanofi aventis.

  • DrugPlacebo
06

What researchers measure

Primary outcomes

  1. The increase of Laser Doppler Blood Flow after the second current stimulation

    Time frame: 1 hour

Secondary outcomes

  1. The increase of Laser Doppler Blood Flow after the second current stimulation after aspirin administration

    Time frame: 1 hour

07

Study locations

1 site
  • University Hospital
    Angers, Maine et Loire 49933, France
08

References and documents

Publications

  • Mahe G, Abraham P, Humeau-Heurtier A, Gascoin L, Leftheriotis G, Durand S. Evidence for a vasomotor cyclo-oxygenase dependent mechanism of sensitization at the cutaneous level. Br J Clin Pharmacol. 2015 Aug;80(2):185-92. doi: 10.1111/bcp.12623. Epub 2015 May 26. PubMed 25753207 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 12, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01572961
Lead sponsor
University Hospital, Angers
Responsible party
Sponsor
First posted
Apr 6, 2012
Start date
Nov 2010
Primary completion
Mar 2012
Completion
May 2013
Last update
Feb 12, 2016

Study contacts

Guillaume Mahe, M.D., Ph.D.
principal investigator · University hospital of Angers

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2016. You cannot join it, but the record below documents what was studied.

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