A Phase 4 interventional study of Propofol and dexmedetomidine and propofol and remifentanil in Chronic Sinusitis, sponsored by Yonsei University. Completed at 1 site in Korea, Republic of. Open to participants aged 20 Years to 70 Years. Per ClinicalTrials.gov, last updated 2014-03-05.
Sponsored by Yonsei University · Phase 4, Interventional, and Prevention
Various maneuvers are commonly used to achieve the ideal operative field necessary for successful endoscopic sinus surgery (ESS). Dexmedetomidine, a potent alpha2 adrenoceptor agonist which dose-dependently reduces arterial blood pressure and heart rate, decreases the hemodynamic and catecholamine response. And dexmedetomidine has an effect of peripheral vasoconstriction thus it is thus theologically appropriate for reducing bleeding during intranasal operation.
The aim of this study is to compare the effect of dexmedetomidine, an alpha2-adrenoreceptor agonist, on intraoperative bleeding, propofol requirement and postoperative profiles to remifentanil , an ultrashort-acting opioid.
415 studies on the registry are indexed under Sinusitis; 46 are open to participants now.
This study's enrollment of 66 is close to the median of 60 across 313 interventional studies indexed under Sinusitis.
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Drug: propofol and remifentanil
Drug: Propofol and dexmedetomidine
Both group : propofol effect site TCI 2-4 mcg/ml, Remifentanil group : remifentanil effect site-TCI 2-4ng/ml Dexmedetomidine group: dexmedetomidine 0.5mcg/kg loading and 0.5mcg/kg/hr infusion
Both group : propofol effect site TCI 2-4 mcg/ml, Remifentanil group : remifentanil effect site-TCI 2-4ng/ml Dexmedetomidine group: dexmedetomidine 0.5mcg/kg loading and 0.5mcg/kg/hr infusion
surgical satisfaction about visibility of operative field
subjective satisfaction about visibility of operative field by surgeon/ numerous rating scale / 0: worst - 10:best
Time frame: Within 1 day of endoscopic sinus surgery finish including dressing of surgical wound
This study is completed, as verified in Mar 2014. You cannot join it, but the record below documents what was studied.
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Yonsei University