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CompletedNCT01545167NAPSUpdated Sep 15, 2017

The North American Pancreatitis Study

An observational study in Pancreatitis, sponsored by University of Pittsburgh. Completed at 1 site in United States. Open to participants aged 14 Years to 100 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-09-15.

Sponsored by University of Pittsburgh · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
2,980
Ages
14 Years to 100 Years
Sex
All
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Study summary

This study will investigate several genes and other factors measured in the blood that may cause recurrent acute pancreatitis and chronic pancreatitis. No treatment is offered as part of this study. Subjects have one single visit to provide a blood sample for genetic testing and to answer a questionnaire. Subjects are not given results of genetic testing. The study is currently enrolling African American subjects and controls only.

Read the detailed description

This study seeks to enroll African American people with and without pancreatitis. There is only one study visit to obtain consent, a blood sample and complete a questionnaire. Subjects must be patients of a participating center; controls must present to a participating center for enrollment.

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Conditions studied

  • Pancreatitis

Browse trials for

Keywords

  • African Americans
  • pancreatitis
  • controls
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In context

Pancreatitis

751 studies on the registry are indexed under Pancreatitis; 180 are open to participants now.

This study's enrollment of 2,980 is above the median of 179 across 276 observational studies indexed under Pancreatitis.

Browse Pancreatitis studies →

Lead sponsor

University of Pittsburgh is the lead sponsor of 1,385 studies on the registry; 167 are open to participants now.

Of its 8 completed or terminated interventional studies of FDA-regulated products, 4 (50%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
14 Years to 100 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

people with and without pancreatitis

Inclusion criteria

African American

pancreatitis patients who are at least 14 years of age with a diagnosis of acute or chronic pancreatitis

  • controls who do not have pancreatitis and must be at least 18 years of age

Exclusion criteria

Exclusion Criteria:

  • unable or unwilling to sign informed consent
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Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
2,980 participants (actual)
Biospecimen retention
Samples with dna

Groups and cohorts

  • African Americans with pancreatitis

    pancreatitis

    Genetic: blood sampling

  • African Americans without Pancreatitis controls

    people without pancreatitis

    Genetic: blood sampling

Interventions

  • Geneticblood sampling

    blood samples obtained to extract biomarkers and dna for analysis, questionnaires

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Study locations

1 site
  • University of Pittsburgh
    Pittsburgh, Pennsylvania 15213, United States
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References and documents

Publications

  • Dunbar EK, Greer PJ, Amann ST, Alkaade S, Banks P, Brand R, Conwell DL, Forsmark CE, Gardner TB, Guda NM, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Slivka A, Wilcox CM, Yadav D, Whitcomb DC; NAPS2 Consortium. Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain. Am J Gastroenterol. 2021 Oct 1;116(10):2128-2136. doi: 10.14309/ajg.0000000000001366. Erratum In: Am J Gastroenterol. 2022 Feb 1;117(2):359. doi: 10.14309/ajg.0000000000001549. PubMed 34236339 ↗
  • Dunbar E, Greer PJ, Melhem N, Alkaade S, Amann ST, Brand R, Cote GA, Forsmark CE, Gardner TB, Gelrud A, Guda NM, LaRusch J, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Wilcox CM, Singh VK, Yadav D, Whitcomb DC; NAPS2 study group. Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort. J Gastroenterol. 2020 Oct;55(10):1000-1009. doi: 10.1007/s00535-020-01703-w. Epub 2020 Jul 17. PubMed 32681239 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 15, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01545167
Lead sponsor
University of Pittsburgh
Responsible party
David Whitcomb (Chief, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh) — Principal investigator
First posted
Mar 6, 2012
Start date
Sep 2008
Primary completion
Jun 2014
Completion
Jun 2014
Last update
Sep 15, 2017

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2017. You cannot join it, but the record below documents what was studied.

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Discussion

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