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CompletedNCT01514539Updated Jan 9, 2015

Hormonal Regulation of Postpartum Weight and Presence of Gut Peptides in Human Milk

An interventional study of cross-sectional in Maternal Obesity Syndrome, sponsored by University of Wyoming. Completed at 1 site in United States. Open to female participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-01-09.

Sponsored by University of Wyoming · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
44
Allocation
Non-randomized
Ages
18 Years to 45 Years
Sex
Female
01

Study summary

Hormonal Regulation of Postpartum Weight and Presence of Gut Peptides in Human Milk Studies suggest that childbearing is an important contributor to the development of obesity in many women and that breastfeeding may be protective.

Ghrelin and peptide YY (PYY) are gut hormones involved in appetite regulation and energy homeostasis and are biological neuroendocrine signals that potentially affect body weight and adiposity/

Read the detailed description

Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk.

This study evaluated whether fasting or postprandial ghrelin or PYY is different between lactating and nonlactating postpartum women matched for age, body weight, and adiposity.

Eligibility Criteria: Healthy females, 18+ years old, non-smokers, no major food allergies, first-time mom, currently pregnant or within 1 month of giving birth.

02

Conditions studied

  • Maternal Obesity Syndrome

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Keywords

  • Human milk, Ghrelin,PYY and maternal obesity.
03

In context

Obesity, Maternal

36 studies on the registry are indexed under Obesity, Maternal; 7 are open to participants now.

This study's enrollment of 44 is below the median of 100 across 21 interventional studies indexed under Obesity, Maternal.

Browse Obesity, Maternal studies →

Lead sponsor

University of Wyoming is the lead sponsor of 19 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes

Inclusion criteria

  • Healthy women (non-smokers) at least 18 years old who did not have any pregnancy complications, and gave birth to their first child within one month.
  • The study is open to women who are breastfeeding or formula feeding.

Exclusion criteria

Exclusion Criteria:

  • Smoker,
  • had twins or triples,
  • had any major complication of pregnancy(example,
  • gestational diabetes);
  • have kidney, liver, hormonal, stomach, intestine,lung, heart or blood disease. This also includes high blood pressure;
  • use prescription or over-the-counter medicine or herbal drinks or pills.
  • History of depression, anxiety, disordered eating, other psychological problems, alcoholism or other substance abuse.
  • Severely claustrophobic.
  • Having a strong fear of needles and/or do not feel you can have blood drawn every 30 minutes from a plastic catheter.
  • Are not able to or willing to fully participate in the study, and are pregnant, anemic or have a thyroid problem.
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
44 participants (actual)

Study arms

  • Other
    Four weeks Postpartum Lactating

    women between 18 and 45 who delivered their first child 4 weeks prior and who were currently lactating and planning to lactate for one year postpartum.

    Other: cross-sectional

  • Other
    Control Never Pregnant

    women between 18 and 45 who have never been pregnant

    Other: cross-sectional

Interventions

  • Othercross-sectional

    Monitoring two recently discovered appetite hormones called "ghrelin" and "neuropeptide YY (PYY)." This study evaluated whether fasting or postprandial ghrelin or PYY is different btween lactating and nonlactating postpartum women matched for age, body weight, and adiposity.

06

What researchers measure

Primary outcomes

  1. "Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk"

    Biomedical Research Study that will provide information on reducing maternal obesity.

    Time frame: 5 years

07

Study locations

1 site
  • Nutritional and Exercise Lab University of Wyoming
    Laramie, Wyoming 82071, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 9, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01514539
Lead sponsor
University of Wyoming
Responsible party
Enette Larson-Meyer (Phd, RD, FACSM, University of Wyoming) — Principal investigator
First posted
Jan 23, 2012
Start date
Aug 2009
Primary completion
Apr 2014
Completion
Apr 2014
Last update
Jan 9, 2015

Study contacts

Dawine E. Larson-Meyer, Phd, RD
principal investigator · University of Wyoming

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2015. You cannot join it, but the record below documents what was studied.

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