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CompletedNCT01512719POEMUpdated Oct 2, 2025

POEM- Peroral Endoscopic Myotomy for Esophageal Motility Disorders

An interventional study of POEM in Achalasia, sponsored by Hadassah Medical Organization. Completed at 3 sites in Israel. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-10-02.

Sponsored by Hadassah Medical Organization · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
100
Allocation
Not applicable
Ages
18 Years to 80 Years
Sex
All
01

Study summary

POEM has recently described as an alternative treatment for achalasia in humans. In this procedure the esophageal sphincter is incised through a submucosal tunnel in the esophagus. In this study we aim to perform POEM on achalasia patients.

02

Conditions studied

  • Achalasia

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03

In context

Esophageal Achalasia

140 studies on the registry are indexed under Esophageal Achalasia; 44 are open to participants now.

This study's enrollment of 100 is above the median of 60 across 93 interventional studies indexed under Esophageal Achalasia.

Browse Esophageal Achalasia studies →

Lead sponsor

Hadassah Medical Organization is the lead sponsor of 659 studies on the registry; 54 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patients with Achalasia whom are candidates for Heller Myotomy

Exclusion criteria

Exclusion Criteria:

  • Perforation of LES during dilatation
  • Pregnant women
  • mentally ill patients
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
100 participants (actual)

Study arms

  • Experimental
    POEM procedure

    Patients with achalasia that undergo POEM

    Procedure: POEM

Interventions

  • ProcedurePOEM

    Per Oral Endoscopic Myotomy for achalasia

06

What researchers measure

Primary outcomes

  1. Resolution of dysphagia

    Time frame: up to 6 months postoperatively

07

Study locations

3 sites
  • Hadassah Medical Center
    Jerusalem, 12000, Israel
  • Hadassah Medical Organization
    Jerusalem, 91120, Israel
  • Hadassah Medical Organization Ein-Kerem campus
    Jerusalem, Israel
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 2, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01512719
Lead sponsor
Hadassah Medical Organization
Responsible party
Sponsor
First posted
Jan 19, 2012
Start date
Jan 2013
Primary completion
Jan 2023
Completion
Jan 2023
Last update
Oct 2, 2025

Study contacts

Yoav Mintz, MD
principal investigator · Hadassah Medical Organization

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.

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