An observational study in Ischemic Stroke, sponsored by Sorlandet Hospital HF. Completed at 1 site in Norway. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-02-08.
Sponsored by Sorlandet Hospital HF · Observational
Stroke is among the most disabilitating diseases worldwide in terms of numbers affected and its consequences. A relatively new and well documented treatment of acute ischemic stroke today is tPA (tissue plasminogen activator; will be called thrombolysis from now on) Unfortunately only a minority of patients is given this treatment.
The large randomised controlled trials that investigated the safety and efficacy of thrombolytic therapy in treatment of acute stroke did not include patients over 80 years. In an aging population in the western world it will be of importance to investigate whether this treatment is safe and effective in this group.
Both Sorlandet hospital Kristiansand Norway and Bergen hospital have administered thrombolysis to selected patients over 80 years the last years. In addition there has been a registration of patients in stroke registers at both locations. This lays a foundation for further investigation. In association with Bergen the investigators have included 77 patients over 80 years treated with thrombolysis. In addition the investigators have 85 patients treated with tpa below 80 years. In our cohort the investigators are going to compare outcome in the 2 groups. In addition the investigators are going to perform a regression analysis of selected variables to see if there is an association of those variables with predefined outcome measures. Our outcome measures is as follows: mRS=6 (death)and mRS 0-1(good outcome) on 3 months control. The third outcome measure will be developement of sICH secondary to tPA treatment. As definition of sICH we have chosen the same definition as Ecass.
7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.
This study's enrollment of 162 is close to the median of 160 across 1,692 observational studies indexed under Stroke.
Browse Stroke studies →Sorlandet Hospital HF is the lead sponsor of 73 studies on the registry; 12 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Sorlandet hospital is a secondary hospital. The patients will be drawn from thrombolysis treated patients in its catchement area. A registry of these patients has been ongoing since before the inclusiondate. All thrombolysed patients at Sorlandet will be included in the predefined inclusionperiode. In addition we have enrolled 39 patients treated with thrombolysis from Haukeland hospital; Bergen. These 77 patients over 80 years will be compared to 85 patients below 80 years treated at SSK in the same defined periode.
Inclusion Criteria:
Two patients were excluded due to missing data at three months control
To study the outcome of stroke patients over 80 years treated with thrombolysis.
Intravenous thrombolysis for acute ischemic stroke with 4.5 hours time-window and no upper age limit
Functional outcome and complications 3 months after thrombolysis in patients over 80 and under 80 years.
Time frame: 2007-2010 (3 yrs)
This study is completed, as verified in Dec 2011. You cannot join it, but the record below documents what was studied.
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Sorlandet Hospital HF