An interventional study of Sevoflurane and Propofol in Anesthesia, sponsored by Ruijin Hospital. Completed at 1 site in China. Open to male participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2015-05-22.
Sponsored by Ruijin Hospital · Not applicable, Interventional, and Prevention
Most researches revealed that volatile anesthetic sevoflurane has a more marked cardioprotective effect against ischemia compared with intravenous agent propofol.However, propofol has been suggested to be more benefit for attenuation of surgery-induced immunosuppression.Thus, the aim of this study was to investigate under the specific OPCAB surgical stress, the influence of 3 established anesthetic techniques: sevoflurane, propofol and combine of sevoflurane and propofol maintained anesthesia on the apoptosis of circulating lymphocytes.
Ruijin Hospital is the lead sponsor of 667 studies on the registry; 376 are open to participants now.
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Drug: Sevoflurane
Drug: Propofol
Drug: combine of sevoflurane and propofol
anesthesia was maintained with sevoflurane (end-tidal concentration 1.0-1.5 minimum alveolar concentration)
anesthesia was maintained with propofol (2-4 μg/ml via target-controlled infusion)
anesthesia was maintained with a combine of propofol (1 μg/ml via target-controlled infusion) and sevoflurane (end-tidal concentration 0.7-1.0 minimum alveolar concentration)
Lymphocyte Count
Blood samples were obtained 24 h after the surgery for routine blood examination. This analysis was performed in the hospital laboratory using routine laboratory procedures.
Time frame: 1 day after surgery
Intensive Care Unit Staying Days
Time frame: participants will stay in intensive care unit after surgery, an expected average of 2 days
Patient recruitment took place from October 9, 2011 to January 12, 2012 in Ruijin Hospital. A total of 149 patients scheduled to undergo elective OPCABG surgery were assessed for eligibility, with 105 patients enrolled and allocated randomly.
| Milestone | Sevoflurane | Propofol | Combine of Sevoflurane and Propofol |
|---|---|---|---|
| Started | 35 | 35 | 35 |
| Completed | 33 | 34 | 33 |
| Not completed | 2 | 1 | 2 |
| Withdrew: Physician decision | 2 | 1 | 2 |
Blood samples were obtained 24 h after the surgery for routine blood examination. This analysis was performed in the hospital laboratory using routine laboratory procedures.
| cells/nanoliter | Sevoflurane | Propofol | Combine of Sevoflurane and Propofol |
|---|---|---|---|
| Lymphocyte Count | 0.55 ± 0.25 | 0.73 ± 0.27 | 0.73 ± 0.31 |
Results for this outcome have not been posted.
Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Sevoflurane | — | 0/33 (0%) | 0/33 (0%) |
| Propofol | — | 0/34 (0%) | 0/34 (0%) |
| Combine of Sevoflurane and Propofol | — | 0/33 (0%) | 0/33 (0%) |
| Age, Continuous(years) | Sevoflurane | Propofol | Combine of Sevoflurane and Propofol | Total |
|---|---|---|---|---|
| Mean | 61 ± 8 | 62 ± 8 | 65 ± 9 | 63 ± 8 |
| Sex: Female, Male(Participants) | Sevoflurane | Propofol | Combine of Sevoflurane and Propofol | Total |
|---|---|---|---|---|
| Female | 33 | 34 | 33 | 100 |
| Male | 0 | 0 | 0 | 0 |
| Region of Enrollment(participants) | Sevoflurane | Propofol | Combine of Sevoflurane and Propofol | Total |
|---|---|---|---|---|
| China | 33 | 34 | 33 | 100 |
This study is completed, as verified in May 2015. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Sevoflurane · Propofol