An observational study in Induced Pluripotent Stem Cells, sponsored by Rambam Health Care Campus. Status unknown at 2 sites in Israel. Open to male participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-12-11.
Sponsored by Rambam Health Care Campus · Observational
Human cells are diploid (contain a double set of chromosomes). The diploid genome is complex and therefore limits genetic research approaches in biomedical models. To overcome this problem experimental generation of haploid stem cells has been done in animals. The investigators aim at generating haploid stem cells from human germ cells that are a useful tool in genetic research and screening.
Human cells are diploid (contain a double set of chromosomes). The diploid genome is complex and therefore limits genetic research approaches in biomedical models. To overcome this problem experimental generation of haploid stem cells has been done in animal models. haploid cells are easier for genetic manipulations, such as knock-in and knock-out of genes, and therefore should make a better experimental model. The investigators aim at generating haploid stem cells from human haploid germ cells.
Rambam Health Care Campus is the lead sponsor of 456 studies on the registry; 33 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Male volunteers
Exclusion Criteria:
Other: generation of stem cells
Collected germ cells will be cultured in medium. The germ cell cultures will be infected with reprograming factors. Rare colonies with characteristic stem cell morphologies will be expanded.
Also known as: generation of stem cells from somatic haploid germ cells
Patients donated samples
No samples collected to date
Time frame: June 2011-November 2013
No secomdary outcome
Time frame: June 2011 - November 2013
This study is status unknown, as verified in Dec 2013. You cannot join it, but the record below documents what was studied.
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Rambam Health Care Campus