An Early Phase 1 interventional study of Diet oil and Olive oil in Type 2 Diabetes Mellitus, sponsored by University of Copenhagen. Completed at 1 site in Denmark. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2014-12-02.
Sponsored by University of Copenhagen · Early Phase 1, Interventional, and Basic science
Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone.
Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone. The aim of the study is to elucidate the effect of 2-OG, 'diet oil' on GLP-1 secretion in patients with type 2 diabetes and to explain the mechanism behind the known stimulation of GLP-1 release by dietary fat.
9,359 studies on the registry are indexed under Diabetes Mellitus, Type 2; 1,318 are open to participants now.
This study's enrollment of 12 is below the median of 80 across 7,525 interventional studies indexed under Diabetes Mellitus, Type 2.
Browse Diabetes Mellitus, Type 2 studies →University of Copenhagen is the lead sponsor of 450 studies on the registry; 61 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Dietary Supplement: Diet oil
Dietary Supplement: Olive oil
Dietary Supplement: Carrot
Carrot and diet oil (containing 2-OG) and 1½ g of paracetamol
Carrot and olive oil and 1½ g of paracetamol
Carrot and 1½ g of paracetamol
Plasma GLP-1
Glp-1 response is measured during and three hours after ingestion of the different mealtest
Time frame: 3 hours
Plasma insulin
Plasma insulin is measured during and 3 hours after mealtest
Time frame: 3 hours
Plasma glucose
Plasma glucose is measured during and 3 hours after meal test
Time frame: 3 hours
Plasma GIP
Plasma GIP is measured during and 3 hours after meal test
Time frame: 3 hours
Plasma glucagon
Plasma glucagon is measured during and 3 hours after meal test
Time frame: 3 hours
Plasma PYY
Plasma PYY is measured during and 3 hours after meal test
Time frame: 3 hours
Plasma paracetamol
Plasma paracetamol is measured during and 3 hours after meal test
Time frame: 3 hours
This study is completed, as verified in Dec 2014. You cannot join it, but the record below documents what was studied.
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University of Copenhagen