An interventional study of Exercise - caloric balance and No Exercise - hyper-caloric diet in Obesity, sponsored by University of Michigan. Completed at 1 site in United States. Open to female participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-11-23.
Sponsored by University of Michigan · Not applicable, Interventional, and Basic science
Alterations in fatty acid mobilization and oxidation may be primary adaptations responsible for the improvements in metabolic health after a single session of endurance exercise. The investigators will determine the effect of a single session of endurance exercise on whole-body fatty acid mobilization and oxidation, IMTG concentration and the expression of factors that regulate these processes in skeletal muscle of 11 women with abdominal obesity (age: 18-45y). In addition, the investigators will evaluate how these factors, and exercise, effect insulin signalling and insulin sensitivity. Every effort will be made to recruit subjects from ethnic and minority groups. Before participating in the study, subjects will be informed of all the procedures and potential risks, and they will sign an informed consent form approved by The University of Michigan Institutional Review Board. Eligible volunteers will participate in three separate trials, in a randomized order. In two trials subjects will eat exactly the same amount of calories, except in one trial they will exercise (eucaloric + exercise) and in the other trial they will remain sedentary (hypercaloric). In a third trial subjects will again remain sedentary but instead they will ingest appropriate calories to maintain caloric balance (eucaloric + sedentary). By doing this the investigators are also able to investigate the effect of acute caloric perturbations on insulin sensitivity, because it is possible that the enhanced insulin sensitivity evident after exercise, as compared to the sedentary state, is due to caloric deficit and not the exercise bout, per se.
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This study's enrollment of 7 is below the median of 78 across 4,878 interventional studies indexed under Obesity.
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Exclusion Criteria:
90 min exercise on Day 1
Other: Exercise - caloric balance
Subjects remain sedentary on Day 1 and will either consume a hyper-caloric or a caloric balanced diet
Other: No Exercise - hyper-caloric diet · Other: No exercise - caloric balance
90 min exercise on Day 1 with meals afterward resulting in caloric balance for the day (i.e.; extra kcals provided to account for energy expended during exercise)\]
Subjects remain sedentary on Day 1 and they ingest meals that are identical to those ingested on the day they performed exercise (i.e.; more calories ingested than expended because no exercise performed).
Subjects remain sedentary on Day 1 and they ingest a similar proportion of macronutrients however, the total calories ingested will be lower than the other two trials, resulting in caloric balance for the day.
Insulin Sensitivity
frequently sampled intravenous glucose tolerance test(FSIVGTT)will be done to assess insuiln sensitivity
Time frame: 3 hours
This study is completed, as verified in Nov 2016. You cannot join it, but the record below documents what was studied.
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University of Michigan