An interventional study of Effects of a Nordic diet rich in plant-based foods and fish in Prehypertension and Hypertension, sponsored by Finnish Institute for Health and Welfare. Completed at 1 site in Finland. Open to participants aged 45 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-10-15.
Sponsored by Finnish Institute for Health and Welfare · Not applicable, Interventional, and Treatment
The purpose of this study is to investigate the effects of a Nordic diet rich in plant-based foods and fish on indicators of cardiovascular disease risk at two different levels of salt intake.
The study is a 20-wk randomized controlled crossover trial. The subjects follow a salt-restricted diet during the study. The study begins with a 4-wk run-in phase for all subjects. After that the subjects are randomly allocated to one of two groups. Group 1 consumes a healthy Nordic low-salt diet enriched with plant-based foods and fish for 16 weeks. Group 2 consumes a low-salt diet for 16 weeks. During the 16 weeks, both groups receive salt and placebo capsules in a double-blind, crossover fashion (8+8 weeks).
145 studies on the registry are indexed under Prehypertension; 21 are open to participants now.
This study's enrollment of 111 is above the median of 62 across 127 interventional studies indexed under Prehypertension.
Browse Prehypertension studies →Finnish Institute for Health and Welfare is the lead sponsor of 43 studies on the registry; 3 are open to participants now.
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Exclusion Criteria:
The subjects consume plant based foods (fruits, berries, vegetables, whole grain) and fish in addition to a salt-restricted diet. Intake of salt is normal to high for 8 weeks and low for 8 weeks (subjects receive salt and placebo capsules in a crossover design).
Other: Effects of a Nordic diet rich in plant-based foods and fish
The subjects follow a salt-restricted diet. Intake of salt is normal to high for 8 weeks and low for 8 weeks (subjects receive salt and placebo capsules in a crossover design).
Other: Effects of a Nordic diet rich in plant-based foods and fish
The intervention lasts for 20 weeks and it includes dietary counseling concerning salt restriction. Key foods are provided to the subjects.
Change from baseline in systolic and diastolic blood pressure after treatments
Time frame: 12 and 20 weeks
Change from baseline in PFA-100 measurements after treatments
Time frame: 12 and 20 weeks
Change from baseline in biomarkers of cardiovascular disease risk after treatments
Time frame: 12 and 20 weeks
Change from baseline in nutritional biomarkers after treatments
Time frame: 12 and 20 weeks
Change from baseline in blood cell gene expression after treatments
Time frame: 12 and 20 weeks
This study is completed, as verified in Oct 2014. You cannot join it, but the record below documents what was studied.
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Finnish Institute for Health and Welfare