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CompletedNCT01389921Updated Jul 23, 2019

Study of Electroencephalogram (EEG) Measurement During Different Stimulations of the Lower Urinary Tract

An interventional study of Electroencephalography in Healthy, Nonneurogenic Neurogenic Bladder Dysfunction and Neurogenic Bladder Dysfunction Nos, sponsored by Ulrich Mehnert. Completed at 1 site in Switzerland. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-07-23.

Sponsored by Ulrich Mehnert · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
83
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of this study is to investigate afferent and cortical activities during bladder filling under different stimulations of the lower urinary tract. The participants of the study are healthy test persons and patients with overactive bladder.

02

Conditions studied

  • Healthy
  • Nonneurogenic Neurogenic Bladder Dysfunction
  • Neurogenic Bladder Dysfunction Nos

Keywords

  • lower urinary tract
  • sensory evoked potential
  • contact heat evoked potential stimulation
  • electroencephalogram
  • cortical processing
  • bladder sensations
  • lower urinary tract dysfunction
  • overactive bladder
03

In context

Urinary Bladder, Neurogenic

185 studies on the registry are indexed under Urinary Bladder, Neurogenic; 40 are open to participants now.

This study's enrollment of 83 is above the median of 36 across 124 interventional studies indexed under Urinary Bladder, Neurogenic.

Browse Urinary Bladder, Neurogenic studies →

Lead sponsor

Ulrich Mehnert is the lead sponsor of 3 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Right-handed
  • Written informed consent

Exclusion criteria

Exclusion Criteria:

  • Any psychological diseases
  • Any renal, cardiac, and pulmonary diseases
  • Pregnancy or breastfeeding
  • Problems keeping calm for 60 minutes in the sitting position
  • Medication influencing EEG or bladder function
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
83 participants (actual)

Study arms

  • Experimental
    healthy testpersons

    Electroencephalography recording during electrical stimulation of different locations of the lower urinary tract as well as during electrical and heat stimulation at the tibial and pudendal nerve and S3 dermatome.

    Other: Electroencephalography

  • Experimental
    patients with non-neurogenic OAB

    Electroencephalography recording during electrical stimulation of different locations of the lower urinary tract as well as during electrical and heat stimulation at the tibial and pudendal nerve and S3 dermatome.

    Other: Electroencephalography

  • Other
    patients with neurogenic OAB

    Electroencephalography recording during electrical stimulation of different locations of the lower urinary tract as well as during electrical and heat stimulation at the tibial and pudendal nerve and S3 dermatome

    Other: Electroencephalography

Interventions

  • OtherElectroencephalography

    Standard electroencephalography investigation according to the ICS standard Current recording of latency and amplitude of evoked potentials

06

What researchers measure

Primary outcomes

  1. Establishment of somatosensory evoked potentials of lower urinary tract stimulations

    EEG recording during electrical stimulation of different locations of the lower urinary tract as well as during electrical and heat stimulation at the tibial and pudendal nerve and S3 dermatome.

    Time frame: 3 times on an average period of three months

07

Study locations

1 site
  • Spinal Cord Injury & Research, University of Zürich, Balgrist University Hospital
    Zürich, 8008, Switzerland
08

References and documents

Publications

  • Gregorini F, Knupfer SC, Liechti MD, Schubert M, Curt A, Kessler TM, Mehnert U. Sensory evoked potentials of the bladder and urethra in middle-aged women: the effect of age. BJU Int. 2015 Apr;115 Suppl 6:18-25. doi: 10.1111/bju.13066. PubMed 25626360 ↗
  • Knupfer SC, Liechti MD, Gregorini F, De Wachter S, Kessler TM, Mehnert U. Sensory function assessment of the human male lower urinary tract using current perception thresholds. Neurourol Urodyn. 2017 Feb;36(2):469-473. doi: 10.1002/nau.22956. Epub 2016 Jan 15. PubMed 26773330 ↗
  • Gregorini F, Wollner J, Schubert M, Curt A, Kessler TM, Mehnert U. Sensory evoked potentials of the human lower urinary tract. J Urol. 2013 Jun;189(6):2179-85. doi: 10.1016/j.juro.2012.11.151. Epub 2012 Nov 30. PubMed 23206421 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 23, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01389921
Lead sponsor
Ulrich Mehnert
Collaborators
NCCR (National Center of Competence in Resaerch, Switzerland)
Responsible party
Ulrich Mehnert (Executive physician, University of Zurich) — Sponsor-investigator
First posted
Jul 8, 2011
Start date
Feb 2011
Primary completion
Sep 2011
Completion
Apr 2014
Last update
Jul 23, 2019

Study contacts

Ulrich Mehnert, Dr.
principal investigator · Neuro-Urology, Spinal Cord Injury Center & Research, University of Zürich, Balgrist University Hospital

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2019. You cannot join it, but the record below documents what was studied.

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