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CompletedNCT01361828Updated May 27, 2011

Optic Nerve and Retinal Functions With Bevacizumab

An observational study in Choroidal Neovascular Membrane, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 24 Years to 62 Years. Per ClinicalTrials.gov, last updated 2011-05-27.

Sponsored by Cairo University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
45
Ages
24 Years to 62 Years
Sex
All
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Study summary

The purpose of this study is to investigate the possible affection of optic nerve and retinal functions following intravitreal bevacizumab injection in human eyes.

Read the detailed description

To evaluate the retinal and optic nerve functions of bevacizumab when injected intravitreal in human eyes using electrophysiological tests; Electroretinogram (ERG) and Visual Evoked Potentials (VEP). Forty five eyes of 45 patients with choroidal neovascular membrane (CNV) who were prepared for intravitreal injections of 1.25mg bevacizumab underwent baseline ERG and VEP in both eyes before, and at 1 and 4 weeks after the intravitreal injections.

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Conditions studied

  • Choroidal Neovascular Membrane

Keywords

  • Bevacizumab
  • VEP
  • ERG
  • Optic nerve and retinal functions following intravitreal bevacizumab
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In context

Lead sponsor

Cairo University is the lead sponsor of 4,909 studies on the registry; 1,445 are open to participants now.

Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
24 Years to 62 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Forty five eyes of 45 patients with choroidal neovascular membrane (CNV) who were prepared for intravitreal injections of 1.25mg bevacizumab underwent baseline ERG and VEP in both eyes before, and at 1 and 4 weeks after the intravitreal injections.Mean age was 50 years ranging from 24-62 years with 25 females, with 28 AMD and 17 myopic patients.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • CNV

Exclusion criteria

Exclusion Criteria:

  • Previous Intravitreal Injections
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
45 participants (actual)

Groups and cohorts

  • Patients with choroidal neovascularization

    CNV due to Age-Related Macular Degenerations and Myopia were included.

    Procedure: Electrophysiology

Interventions

  • ProcedureElectrophysiology

    Visual Evoked Potential and Elctroretinogram

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What researchers measure

Primary outcomes

  1. Visual Evoked Potential and Electroretinogram

    VEP and ERG baseline and at 1 and 4 weeks post intravitreal injection of bevacizumab.

    Time frame: 4 weeks

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Study locations

1 site
  • Cairo University
    Cairo, --- Select One --- 11421, Egypt
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References and documents

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 27, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01361828
Lead sponsor
Cairo University
First posted
May 27, 2011
Start date
Jan 2010
Primary completion
Jul 2010
Completion
Jul 2010
Last update
May 27, 2011

Study contacts

Tamer A macky
principal investigator · Cairo University

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2010. You cannot join it, but the record below documents what was studied.

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