An observational study in Defect of Articular Cartilage, Osteochondral Lesion of Talus and Osteochondritis Dissecans, sponsored by Zimmer Orthobiologics, Inc.. Status unknown at 8 sites in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-01-26.
Sponsored by Zimmer Orthobiologics, Inc. (part of Zimmer Biomet) · Observational
Among 13 studies in Osteochondritis Dissecans with a site in United States — 4 open to participants now, 4 under way, 1 of them phase 3. Osteochondritis Dissecans · United States.
Among the 13 studies in Osteochondritis Dissecans with a site in United States, this one is one of 4 that started in 2011, is one of 6 observational ones, and was the 3rd registered.
30 studies on the registry are indexed under Osteochondritis Dissecans; 7 are open to participants now.
Browse Osteochondritis Dissecans studies →4 of the 13 studies in Osteochondritis Dissecans with a site in United States are open now. Recruiting first, the newest first:
Fin-Ceramica Faenza Spa · Sites in United States, Italy
Ages 18–60
Vericel Corporation · Sites in United States
Ages 10–17
University of Pennsylvania · Sites in United States
Duke University · Sites in United States
Ages 18–85
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 6 Osteochondritis Dissecans studies recruiting now, 2 set no upper age limit and 4 stop at 75 or younger; 5 take children under 18; none take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
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13 studies; the count open now beside each. This study's row is marked.
First in 2010; this study’s year is marked. 4 started in 2011.
This study's enrollment of 205 is above the median of 130 across 12 observational studies indexed under Osteochondritis Dissecans.
Median enrollment 75 across the 7 interventional studies, 130 across the 6 observational. Of the 6 that completed or were terminated, 1 (17%) have results posted.
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6 of 13 have an industry lead sponsor. The 10 most frequent:
Zimmer Orthobiologics, Inc. is the lead sponsor of 5 studies on the registry; none are open to participants now.
Zimmer Biomet has 3 studies filed under Osteochondritis Dissecans — fewer than ten, so there is no comparison to draw.
1 of the studies in Osteochondritis Dissecans with a site in United States that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT02664337Duke UniversityConjoint Analysis of Patient Preferences in Joint Interventions | 2027-07 |
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Among the 13 studies in Osteochondritis Dissecans with a site in United States, from their registry updates:
Nothing recorded among them since 2026-09-25.
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The purpose of this post-market clinical study is to collect long-term outcomes for DeNovo NT Graft treatment of articular cartilage lesions in the ankle in a standard clinical setting. Outcomes to be assessed include pain, function, activity levels and healthcare resource use.
Articular cartilage lesions in the ankle can cause significant pain and loss of function for young to middle age adults. There are several treatment options for symptomatic articular cartilage injuries depending on a patient's age, symptoms and duration of complaints in addition to the size and condition of the lesion. DeNovo NT Natural Tissue Graft is comprised of fresh particulated juvenile cartilage pieces that are secured inside articular cartilage lesions using fibrin adhesive. DeNovo NT Graft was developed due to the current need for expanded treatment options for the treatment of cartilage lesions, especially large lesions.
This post-market, multicenter, longitudinal data collection study was established to collect clinical outcomes of subjects implanted with DeNovo NT Graft. Data may be obtained either retrospectively or prospectively from patients implanted or to be implanted with DeNovo NT Graft for the treatment of lesion in the ankle. Data to be collected include details of the operative procedure as well as subject pain, function, activity levels, and healthcare resource use through a five year post-operative follow-up period.
Subjects who have received or who are scheduled to receive a DeNovo NT graft for repair of a cartilage lesion in the ankle.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Potential subjects are screened for study entry based on a preliminary review of the inclusion and exclusion criteria as it applies to their pre-operative status (unless otherwise noted).
Inclusion Criteria:
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Autoimmune disease
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Subjects who have received or who are scheduled to receive a DeNovo NT Graft for repair of a cartilage lesion in the ankle.
Other: DeNovo NT Natural Tissue Graft
DeNovo NT is a juvenile cartilagenous tissue graft, inclusive of a viable human cartilage cells. It is provided as particulated tissue pieces of approximately 1mm3 each
Also known as: DeNovo NT
Mean scores from patient-reported clinical outcome surveys
Time frame: 5 years
Incidence of reoperations and revision surgeries
Time frame: 5 years
The record gives a start of Mar 2011, a primary completion of Jul 2019 and a completion of Sep 2019. It does not say whether these dates are actual or estimated.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Jan 2017. You cannot join it, but the record below documents what was studied.
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