CClinicalTrials.gg
CompletedNCT01346995Updated May 4, 2011

The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

An interventional study of Experimental knee pain and Non-painful control injections in Muscle Strength, sponsored by Frederiksberg University Hospital. Completed. Open to participants aged 20 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2011-05-04.

Sponsored by Frederiksberg University Hospital · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
36
Allocation
Randomized
Ages
20 Years to 35 Years
Sex
All
01

Study summary

The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

02

Conditions studied

  • Muscle Strength
03

In context

Lead sponsor

Frederiksberg University Hospital is the lead sponsor of 40 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 35 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • aged between 20 to 35 years
  • healthy
  • untrained (non-regular exercise participation [i.e. \< 1 day/week])

Exclusion criteria

Exclusion Criteria:

  • symptomatic musculoskeletal diseases
  • history of traumatic injuries to muscles, tendons or joints of the lower extremity
  • knee joint pain within a month prior to enrollment
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
36 participants (actual)

Study arms

  • Experimental
    Experimental Knee Pain

    Experimental knee pain induced by injections of 1 ml hypertonic saline in to the infrapatellar fat pad

    Other: Experimental knee pain

  • Active comparator
    Control

    non-painful injections of isotonic saline into the infrapatellar fatpad.

    Other: Non-painful control injections

Interventions

  • OtherExperimental knee pain

    Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad

  • OtherNon-painful control injections

    Injection of isotonic saline into the infrapatellar fat pad

06

What researchers measure

Primary outcomes

  1. Isokinetic knee muscle strength

    Time frame: At baseline and after 8 weeks of exercise

Secondary outcomes

  1. One-leg chair rise

    Time frame: At baseline and after 8 weeks of exercise

07

Study locations

No study locations are listed for this record.

08

References and documents

Publications

  • Sorensen TJ, Langberg H, Hodges PW, Bliddal H, Henriksen M. Experimental knee joint pain during strength training and muscle strength gain in healthy subjects: a randomized controlled trial. Arthritis Care Res (Hoboken). 2012 Jan;64(1):108-16. doi: 10.1002/acr.20618. PubMed 21905254 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 4, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01346995
Lead sponsor
Frederiksberg University Hospital
First posted
May 4, 2011
Start date
Feb 2010
Primary completion
Aug 2010
Completion
Aug 2010
Last update
May 4, 2011

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2010. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion