An observational study in Oropharyngeal Cancer and Human Papillomavirus, sponsored by Johns Hopkins Bloomberg School of Public Health. Completed at 4 sites in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-03-03.
Sponsored by Johns Hopkins Bloomberg School of Public Health · Observational
This research is being done to understand more about a sexually transmitted virus called Human papillomavirus (HPV) in people with oropharyngeal cancer and their partners.
This study evaluates oral HPV infection and risk factors in people with head and neck cancer and their partners or spouses. The study focuses on oropharyngeal cancer patients and includes patients with HPV-associated and HPV-unassociated disease. A comparison group of people without cancer (controls) are also being enrolled. Couples are followed longitudinally and there is a repository of study samples. It is hoped that this research will help us understand risk factors for oral HPV infection, persistence and transmission as well as researching biomarkers for HPV-associated oral cancer and survival.
The study is led by Dr Amber D'Souza (Johns Hopkins) and laboratory testing for the study is performed in the laboratory of study co-investigator Dr Maura Gillison (Ohio University). The study biorepository is led by Dr karen Anderson (Arizona State). Participants are being enrolled at four sites across the United States including: Mt Sinai (site PI Dr Marshall Posner), Johns Hopkins (site PI Dr Sara Pai), Dana Farber Cancer Institute (site PI Dr Robert Haddad) and Oregon Health and Science University (site PI Dr Neil Gross).
375 studies on the registry are indexed under Oropharyngeal Neoplasms; 99 are open to participants now.
This study's enrollment of 242 is above the median of 111 across 68 observational studies indexed under Oropharyngeal Neoplasms.
Browse Oropharyngeal Neoplasms studies →Johns Hopkins Bloomberg School of Public Health is the lead sponsor of 364 studies on the registry; 41 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 3 (60%) have results posted.
Counted across the registry records on this site, refreshed daily.
cohort of cancer patients with matched enrollment of spouses and non-cancer controls
Exclusion Criteria:
208 oropharyngeal cancer cases were enrolled
110 partners of patients with oropharyngeal cancer were enrolled
A convenience group of 106 non-cancer controls were enrolled at some study sites at cancer screening events
HPV DNA detection in oral rinse sample
Detection of 17 types of HPV DNA in exfoliated oral cells of cases and partners collected using an oral rinse and gargle
Time frame: baseline
This study is completed, as verified in Feb 2017. You cannot join it, but the record below documents what was studied.
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Johns Hopkins Bloomberg School of Public Health