An observational study in Oropharyngeal Carcinoma, sponsored by University Medical Center Groningen. Not yet recruiting at 1 site in Netherlands. Open to participants aged 16 Years and older. Per ClinicalTrials.gov, last updated 2026-10-08.
Sponsored by University Medical Center Groningen · Observational
This prospective in-silico study evaluates a novel Off-line Adaptive Proton Therapy (o-APT) workflow for patients with oropharyngeal cancer receiving proton therapy. The study assesses whether automated image analysis, treatment plan adaptation, and quality assurance can identify and prepare treatment plan modifications more efficiently than current clinical practice, without affecting patient care.
Proton therapy is highly sensitive to anatomical and positioning changes that may occur during treatment. Current methods for identifying the need for treatment plan adaptation rely on periodic verification imaging and manual review processes, which can delay implementation of adapted treatment plans.
This study evaluates an Off-line Adaptive Proton Therapy (o-APT) workflow designed to support earlier identification of clinically relevant anatomical changes and more efficient treatment plan adaptation. The workflow combines artificial intelligence-based generation of synthetic computed tomography (CT) images from routine cone-beam computed tomography (CBCT) scans, automated treatment plan generation, and automated quality assurance procedures.
The study is conducted using data collected during routine clinical care. The investigational workflow is evaluated in parallel with standard clinical practice and does not influence treatment decisions or patient care. The aim is to assess the feasibility of integrating this workflow into the proton therapy adaptation process and to evaluate its potential to improve the efficiency and timeliness of treatment plan adaptation.
373 studies on the registry are indexed under Oropharyngeal Neoplasms; 97 are open to participants now.
This study's planned enrollment of 100 is close to the median of 111 across 66 observational studies indexed under Oropharyngeal Neoplasms.
Browse Oropharyngeal Neoplasms studies →University Medical Center Groningen is the lead sponsor of 610 studies on the registry; 174 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with oropharyngeal cancer receiving curatively intended proton therapy at the University Medical Center Groningen (UMCG)
Exclusion Criteria:
Patients with oropharyngeal cancer treated with proton therapy
Other: Off-line Adaptive Proton Therapy (o-APT) Workflow Evaluation
Evaluation of an off-line adaptive proton therapy workflow using routinely collected clinical data
Dose Adjustments Ready to Use Before the Next Fraction
Availability of adapted treatment plans before the next treatment fraction
Time frame: From the first to the last radiotherapy fraction, approximately 7 weeks.
Accuracy of early identification of the need for treatment plan adaptation
Accuracy of the o-APT workflow in identifying the need for treatment plan adaptation, with particular focus on positive predictive value and negative predictive value.
Time frame: From the first to the last radiotherapy fraction, approximately 7 weeks.
Plan to share: No — No plan has been made to make individual participant data available to external researchers
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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University Medical Center Groningen