An interventional study of Gabapentin and Placebo in Post Operative Pain and Total Knee Replacement, sponsored by McMaster University. Completed at 1 site in Canada. Open to participants aged 19 Years to 90 Years. Per ClinicalTrials.gov, last updated 2026-06-10.
Sponsored by McMaster University · Not applicable, Interventional, and Treatment
Total knee arthroplasty is amongst the most painful procedures postoperatively, and pain management can be a challenge. Different measures have been introduced to manage severe postoperative pain int hese patients. Previous studies have investigated gabapentin in acute postoperative pain and demonstrated reducted pain, postoperative morphine consumption, morphine related side effects, and postoperative pain scores. To date, this analgesia adjunct has yet to be investigated in total joint arthroplasty patients.
The study was submitted to Health Canada and received the letter of no objection. A randomized, double-blind, placebo-controlled study. The randomization scheme will be prepared and will be done by the pharmacy department at McMaster University. Ninety patients undergoing primary knee arthroplasty will be recruited from the preoperative clinic. Forty-five patients in each population will be allocated to a gabapentin group and the other forty-five to a placebo group.
5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.
This study's enrollment of 101 is above the median of 75 across 4,344 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →McMaster University is the lead sponsor of 720 studies on the registry; 124 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 2 (33%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Gabapentin 600 mg will be given per oral two hours preoperatively and 200 mg three times daily after surgery (600 mg/day).
Drug: Gabapentin
Placebo will match the the gabapentin pill and will be given orally.
Drug: Placebo
600mg of Gabapentin will be given orally preoperatively and 200mg for 3 times a day after surgery for 3 days
Also known as: Neurontin
Placebo will match the the gabapentin pill and will be given orally.
Also known as: Sugar pill
Amount of morphine consumption
Time frame: 2 years
Side effects
Nausea/Vomiting Sedation Pruritis Visual Disturbance Dizziness/Lightheadness
Time frame: 2 years
This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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McMaster University